| Anxiolytic-like effects of sinapic acid in mice. | |
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MedLine Citation:
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PMID: 17570441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sinapic acid is a phenylpropanoid compound and is found in various herbal materials and high-bran cereals. With the exception of its antioxidant activities, the pharmacological properties of sinapic acid have been rarely reported. The purpose of this study was to characterize the putative anxiolytic-like properties of sinapic acid using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). Sinapic acid (4 mg/kg, p.o.) significantly increased the percentages of time spent in the open arms of the EPM test (P<0.05). In the hole-board test, sinapic acid also significantly increased the number of head-dips at 4 mg/kg (P<0.05). In addition, the anxiolytic-like properties of sinapic acid examined in the EPM test were blocked by flumazenil or bicuculline, which are GABA(A) antagonists. Moreover, sinapic acid markedly potentiated GABA current in single cortical neurons in a dose-dependant manner, and reactive I(GABA) increased to 1.8 times at 1 muM of sinapic acid. These results suggested that sinapic acid is a prominent anxiolytic agent, and that its anxiolytic-like effects are mediated via GABA(A) receptors and potentiating Cl(-) currents. |
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Authors:
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Byung Hoon Yoon; Ji Wook Jung; Jong-Ju Lee; Young-Wuk Cho; Choon-Gon Jang; Changbae Jin; Tae Hwan Oh; Jong Hoon Ryu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-21 |
Journal Detail:
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Title: Life sciences Volume: 81 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-08-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 234-40 Citation Subset: IM |
Affiliation:
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Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Hoeki-dong, Dongdaemoon-ku, Seoul 130-701, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Anxiety Agents* Anxiety / drug therapy, psychology Bicuculline / pharmacology Cerebral Cortex / cytology, drug effects, physiology Chloride Channels / drug effects Coumaric Acids / pharmacology* Diazepam / pharmacology Electrophysiology Flumazenil / pharmacology GABA Antagonists / pharmacology GABA Modulators / pharmacology Male Mice Mice, Inbred ICR Motor Activity / drug effects Muscle Relaxation / drug effects Muscle, Smooth / drug effects Neurons / drug effects Neurotransmitter Agents / physiology Piperazines / pharmacology Postural Balance / drug effects Pyridines / pharmacology Serotonin Antagonists / pharmacology gamma-Aminobutyric Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Chloride Channels; 0/Coumaric Acids; 0/GABA Antagonists; 0/GABA Modulators; 0/Neurotransmitter Agents; 0/Piperazines; 0/Pyridines; 0/Serotonin Antagonists; 146714-97-8/WAY 100635; 439-14-5/Diazepam; 485-49-4/Bicuculline; 530-59-6/sinapinic acid; 56-12-2/gamma-Aminobutyric Acid; 78755-81-4/Flumazenil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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