Document Detail

Anxiety modulation by the heart? Aerobic exercise and atrial natriuretic peptide.
MedLine Citation:
PMID:  17010527     Owner:  NLM     Status:  MEDLINE    
Exercise has an anxiolytic activity and it increases the concentrations of atrial natriuretic peptide (ANP). Because ANP has an anxiolytic activity, this hormone might contribute to the anxiolytic effects of aerobic exercise. Cholecystokinin-tetrapeptide (CCK-4)-induced panic attacks were studied in 10 healthy subjects after "quiet rest" or 30 min of aerobic exercise. Plasma ANP concentrations were measured before and after exercise or quiet rest using a commercial IRMA kit. Compared to quiet rest, CCK-4-induced anxiety was reduced and plasma ANP concentrations were increased by prior exercise. This anxiolytic activity of exercise was correlated with the increase in plasma ANP concentrations. Our results suggest that besides other mechanisms, ANP might be a physiologically relevant humoral link between the heart and anxiety-related behavior contributing to the acute anxiolytic effects of exercise.
Andreas Ströhle; Christian Feller; Christian J Strasburger; Andreas Heinz; Fernando Dimeo
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-09-27
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  31     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-09     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1127-30     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Schumannstrasse 20/21, 10117 Berlin, Germany.
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MeSH Terms
Anxiety / blood*,  chemically induced
Atrial Natriuretic Factor / blood*
Exercise / physiology*,  psychology*
Panic Disorder / blood*,  chemically induced
Reference Values
Tetragastrin / administration & dosage
Reg. No./Substance:
1947-37-1/Tetragastrin; 85637-73-6/Atrial Natriuretic Factor

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