Document Detail

Anxiety-like behaviour in adult rats perinatally exposed to maternal calorie restriction.
MedLine Citation:
PMID:  18453007     Owner:  NLM     Status:  MEDLINE    
Environmental stimuli such as caloric availability during the perinatal period exert a profound influence on the development of an organism. Studies in this domain have focused on the effects of under- and malnutrition while the effects of more mild levels of restriction have not been delineated. Rat dams and their offspring were subjected to one of five dietary regimens: control, CR50% for 3 days preconception, CR25% during gestation, CR25% during lactation, and CR25% during gestation, lactation, and post-weaning (lifelong). The pup retrieval test and maternal observations were conducted during lactation to quantify maternal care. In the pup retrieval test, dams that were concurrently experiencing CR (i.e., from the lactation and lifelong groups) displayed shorter latencies to retrieve all pups than the control and preconception groups and the lactation group constructed better nests than all groups. Adult offspring were tested in three tests of anxiety: the elevated plus maze, open field, and emergence test. No differences were observed in the elevated plus maze; however, in the open field preconception animals made fewer entries and spent more time in the central zone than controls. In addition, preconception offspring exhibited longer latencies to full body emergence, spent less time fully emerged, and spent more time engaged in risk assessment behaviours than all other groups. Offspring from the preconception group were also on average 11% heavier than control rats throughout life and displayed 37% higher serum leptin concentrations than controls. A potential role for leptin in the anxiogenic effect of preconception CR is discussed.
Elizabeth A Levay; Antonio G Paolini; Antonina Govic; Agnes Hazi; Jim Penman; Stephen Kent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-25
Journal Detail:
Title:  Behavioural brain research     Volume:  191     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  164-72     Citation Subset:  IM    
School of Psychological Science, La Trobe University, Bundoora, VIC 3086, Australia.
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MeSH Terms
Age Factors
Analysis of Variance
Animals, Newborn
Anxiety / blood,  physiopathology*
Behavior, Animal
Body Weight / physiology
Caloric Restriction / methods*
Embryo, Mammalian
Exploratory Behavior / physiology
Leptin / blood
Maternal Behavior
Maze Learning / physiology
Prenatal Exposure Delayed Effects*
Rats, Wistar
Video Recording / methods
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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