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Anxiety disorders are associated with increased plasma adrenomedullin level and left ventricular hypertrophy in patients with hypertension.
MedLine Citation:
PMID:  23638647     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To investigate the association between anxiety disorders and left ventricular hypertrophy in patients with essential hypertension. Methods: Left ventricular structure and function were assessed with echocardiography in 56 patients with essential hypertension and anxiety disorder (study group) and in 56 patients with hypertension only (control group). Serum adrenomedullin levels were also measured in these patients. Results: There was no statistically significant difference in the left ventricular ejection fraction between the study and the control group (54.21 ± 88.81% versus 56.01 ± 7.85%, p > 0.05). The left ventricular mass index (LVMI) in study group was higher than in control group (137.05 ± 9.42 versus 123.57 ± 7.01 g/m(2), p = 0.001). The plasma levels of adrenomedullin in study group was higher than in control group (25.97 ± 5.48 versus 18.32 ± 6.97 ng/L, p = 0.001). Levels of plasma adrenomedullin were positively correlated with LVMI in the study (r = 0.734, p < 0.05) and control group (r = 0.592, p < 0.05). Conclusion: Anxiety disorders are associated with elevated plasma adrenomedullin levels and increased left ventricular hypertrophy in patients with essential hypertension. The clinical significance of these changes requires further investigation.
Authors:
De-Gui Kong; Hang Gao; Yu-Qiao Lu; Xue-Wen Qi; Long-Le Ma; Xiang-Quan Kong; Dao-Kuo Yao; Le-Xin Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-2
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  -     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Liaocheng People's Hospital of Taishan Medical University , Shandong Province 252000 , China .
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