Document Detail

Anxiety and P wave dispersion in a healthy young population.
MedLine Citation:
PMID:  16131805     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: P wave dispersion (P(d)), defined as the difference between the maximum (P(max)) and the minimum P wave duration (P(min)), and P(max) are electrocardiographic (ECG) markers that have been used to evaluate the discontinuous propagation of sinus impulses and the prolongation of atrial conduction time. P(d) in normal subjects has been reported to be influenced by the autonomic tone, which induces changes in atrial size and the velocity of impulse propagation. However, the association between P(d) and anxiety has not been studied in normal subjects. METHODS AND RESULTS: P(max), P(min) and P(d) were measured in 726 physically and mentally healthy young male volunteers, aged 21.23 +/- 1.25 years (range 20-26). The Spielberger State-Trait Anxiety Inventory (STAI) was scored concomitantly. Blinded intra- and interobserver reproducibility of the P wave duration and P(d) measurement were evaluated, and comparison revealed a Pearson correlation coefficient of 0.87 and 0.89 for the P wave duration, and 0.93 and 0.90 for P(d), respectively (p < 0.001). P(max) and P(d) were significantly correlated with the state anxiety (STAI-1) subscale (r = 0.662, p < 0.001, and r = 0.540, p < 0.001, respectively) and the trait anxiety (STAI-2) subscale (r = 0.583, p < 0.001, and r = 0.479, p < 0.001, respectively). P(min) did not show any significant correlation with anxiety. Across 3 variables included in a multiple linear regression analysis, STAI-1 and STAI-2 were the significant independent determinants of P(max) and P(d). Beta coefficients indicated that the contribution of STAI-1 to P(max) (66.3 and 33.7%) and P(d) (65 and 35%) was much greater than that of STAI-2. CONCLUSIONS: STAI-1 and STAI-2 are associated with an increase in P(max) and P(d). The association of P(d) resulted from an augmentation of P(max). This is the first study to show the relation between P(max), P(d) and anxiety.
Huseyin Uyarel; Hulya Kasikcioglu; Sennur Unal Dayi; Zeynep Tartan; Ahmet Karabulut; Bulent Uzunlar; Hasan Samur; Ibrahim Sari; Ertan Okmen; Nese Cam
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2005-08-29
Journal Detail:
Title:  Cardiology     Volume:  104     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-13     Completed Date:  2006-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Department of Cardiology, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey.
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MeSH Terms
Anxiety / physiopathology*
Heart Conduction System / physiopathology
Observer Variation
Reference Values
Reproducibility of Results
Statistics as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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