Document Detail

Antral hypergastrinemia--a report of three cases.
MedLine Citation:
PMID:  3678636     Owner:  NLM     Status:  MEDLINE    
Three patients with juxtapyloric ulcers and hypergastrinemia are presented. Fasting and food-stimulated serum gastrin concentration (SGC) were measured in 1970, 1972 and 1973 before the primary ulcer operation (selective gastric vagotomy and Jaboulay gastroduodenostomy; SGV + GD). Fasting SGC were 105, 149 and 158 pg/ml and the postprandial concentrations were 400, greater than 800 and greater than 800 pg/ml, respectively. The pentagastrin-stimulated acid secretion was within the normal range. After SGV + GD, only a slight decrease in acid secretion was observed. The hypergastrinemia persisted unchanged or decreased slightly in 1 patient. A recurrent ulcer developed and a precise antrectomy was carried out. Postoperatively, the fasting SGC was markedly reduced and the postprandial gastrin response abolished. The resected specimens were subjected to immunocytochemical gastrin cell quantitation. The number of gastrin cells was elevated in all 3 patients and the gastrin cell topography was distorted, with cells being present both in the lower and upper thirds of the antropyloric glands.
J Poulsen; P Delikaris; L I Larsson; E Amdrup
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Digestion     Volume:  37     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-11     Completed Date:  1988-01-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  211-6     Citation Subset:  IM    
Department of Surgical Gastroenterology, Kommunehospitalet, Arhus University, Denmark.
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MeSH Terms
Gastric Acid / secretion*
Gastrins / blood*,  secretion
Middle Aged
Pyloric Antrum / metabolism,  pathology,  surgery
Stomach Ulcer / blood*,  pathology,  surgery
Reg. No./Substance:

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