Document Detail


Antral gastrin concentration in upper-gastrointestinal disease.
MedLine Citation:
PMID:  842527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antral gastrin concentration (AGC) was measured in prepyloric mucosa specimens obtained by forceps biopsy during endoscopic examination of 174 clinic and hospital patients. AGC in 32 patients who had normal endoscopic findings, the control group, varied widely from 2 to 38.6 ng gastrin/mg tissue. The mean AGC of the control patients was 14.2 +/- 1.4 (mean +/- 1 SE) ng gastrin/mg tissue. AGC was similar to control values in 18 patients with duodenal ulcer, 14.7 +/- 2.1; 12 patients with a pyloric channel or antral ulcer, 16.4 +/- 3.5; and 48 patients with miscellaneous diagnoses, 14.3 +/- 1.5. AGC was significantly less than control values in 13 patients with a ulcer in the body or fundus of the stomach, 5.9 +/- 1.5, and 4 patients with the Zollinger-Ellison syndrome, 4.9 +/- 2.4. AGC was significantly greater than in control values in 16 patients with gastritis, 25.8 +/- 4.3;22 patients with esophagitis, 23.2 +/- 3.0; and 9 patients with gastric atrophy and fasting serum hypergastrinemia 44.6 +/- 12.3. In group of 77 of these patients with heterogeneous diagnoses, meal-stimulated 3-hr integrated gastrin output was directly related to AGC (r = 0.47, P less than 0.001). In a group of 106 patients AGC was inversely related to histalogstimulated maximum acid output. The correlation was very weak (r = -0.20) but significant (P less than 0.05).
Authors:
W S Hughes; N Snyder; A Hernandez
Related Documents :
23718217 - Survey based investigation into general practitioner referral patterns for spinal manip...
25182397 - The feelings of adolescents connected with medical visits and their perception of the p...
12566547 - Evaluation and treatment of dyspepsia.
15007307 - Difference in ulex europaeus agglutinin i-binding activity of decay-accelerating factor...
24807007 - Patient-centered approach to designing sickle cell transition education.
22340997 - The impact of coping strategies on mental and physical well-being in patients with rheu...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of digestive diseases     Volume:  22     ISSN:  0002-9211     ISO Abbreviation:  Am J Dig Dis     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0404011     Medline TA:  Am J Dig Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Atrophy
Biopsy
Duodenal Ulcer / metabolism*
Esophagitis / metabolism
Gastric Mucosa / metabolism
Gastrins / metabolism*
Gastritis / metabolism*
Gastroscopy
Humans
Pyloric Antrum / metabolism*
Stomach / pathology
Stomach Ulcer / metabolism*
Zollinger-Ellison Syndrome / metabolism
Chemical
Reg. No./Substance:
0/Gastrins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased lithogenicity of bile on fasting in normal subjects.
Next Document:  Amyloidosis and inflammatory bowel disease.