| Antiviral resistance by the polyinosinic acid-poly (1-vinylcytosine) complex. | |
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MedLine Citation:
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PMID: 4324924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(I).poly(C)], which is a potent interferon inducer, have been studied. Structural changes that modify the polymer backbone substantially, such as loops or 2' --> 5' phosphodiester bonds, lead to decreased antiviral activity. Unexpectedly, however, the complex of polyinosinic acid and poly(1-vinylcytosine), which is only a much more distantly related analog of poly(I) . poly(C), shows high activity. It is postulated that the high activity is related to the reduction of the charge/mass ratio and to the existence of this complex in an aggregated state; these are two factors that generally enhance the uptake of compo unds by cells. |
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Authors:
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J Pitha; P M Pitha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 172 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1971 Jun |
Date Detail:
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Created Date: 1971-06-30 Completed Date: 1971-06-30 Revised Date: 2011-12-13 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1146-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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pharmacology* Culture Techniques Fibroblasts Interferons / biosynthesis Poly I-C / pharmacology Polynucleotides / chemical synthesis, pharmacology* Polyvinyls / pharmacology Vesicular stomatitis Indiana virus / drug effects* Virus Cultivation |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Polynucleotides; 0/Polyvinyls; 24939-03-5/Poly I-C; 9008-11-1/Interferons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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