Document Detail


Antiviral re-treatment of IFN-Ribavirin non-responders for recurrent post-transplantation hepatitis C.
MedLine Citation:
PMID:  20438578     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Yedibela S, Demir R, Melling N, Aydin Ü, Schuppan D, Müller V, Hohenberger W, Schönleben F. Antiviral re-treatment of IFN-Ribavirin non-responders for recurrent post-transplantation hepatitis C. Clin Transplant 2011: 25: 131-135. © 2010 John Wiley & Sons A/S. Abstract: Background:  The aim of the study was to compare the efficacy and tolerability of pegylated interferon (PEG-IFN) plus ribavirin (RIB) and PEG-IFN monotherapy after unsuccessful initial therapy with interferon-α2b (IFN) plus RIB after recurrent post-transplantation hepatitis C. Methods:  Twenty-four patients with either no response (n = 10) or relapse (n = 14) after treatment with IFN plus RIB were prospectively randomized in the two treatment arms: 1) PEG-IFN monotherapy at a dosage of 0.8 μg/kg per week (n = 12) and 2) PEG-IFN (0.8 μg/kg per week) plus RIB (800-1200 mg/d) (n = 12). Results:  Twenty-one patients (86%) were treated for at least six months. Three patients are still being treated. At the end of therapy, 18 patients (75%) were HCV RNA negative. Five (45%) patients in PEG-IFN and five (50%) in PEG-IFN plus RIB arms had sustained virological response. Two patients (10%) died from recurrent hepatocellular carcinoma. The histologic activity indices significantly improved in both treatment arms. In the PEG-IFN arm, one patient experienced an acute rejection and discontinued therapy. Conclusions:  Both treatment arms showed to be effective, well tolerated and lead to an improvement in histologic outcome. Because of lower rates in side effects and equal outcome, PEG-IFN monotherapy is an adequate option for antiviral re-treatment.
Authors:
Süleyman Yedibela; Resit Demir; Nathaniel Melling; Unal Aydin; Detlef Schuppan; Volker Müller; Werner Hohenberger; Frank Schönleben
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical transplantation     Volume:  25     ISSN:  1399-0012     ISO Abbreviation:  Clin Transplant     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  131-5     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Affiliation:
Department of General Surgery, University of Erlangen-Nuremberg, Krankenhausstr, Erlangen, Germany Department of General Surgery, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey Beth Israel Deaconess Medical Center, Boston, MA, USA.
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