Document Detail

Antiviral effect of ribonuclease conjugated oligodeoxynucleotides targeting the IRES RNA of the hepatitis C virus.
MedLine Citation:
PMID:  19450979     Owner:  NLM     Status:  MEDLINE    
Hepatitis C virus (HCV) translation initiation is mediated by a highly structured and conserved RNA, termed the Internal Ribosome Entry Site (IRES), located at the 5'-end of its single stranded RNA genome. It is a key target for the development of new antiviral compounds. Here we made use of the recently developed HCV cell culture system to test the antiviral activity of artificial ribonucleases consisting of imidazole(s) linked to antisense oligodeoxynucleotides targeting the HCV IRES. Results from the cell culture model indicate that the naked antisense oligodeoxynucleotide displayed an efficient antiviral activity. Despite the increased activity observed with the addition of imidazole moieties when tested with the cell-free system, it appears that these improvements were not reproduced in the cellular model.
Carly Gamble; Maud Trotard; Jacques Le Seyec; Valérie Abreu-Guerniou; Nicolas Gernigon; Fabienne Berrée; Bertrand Carboni; Brice Felden; Reynald Gillet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-04
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-09     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3581-5     Citation Subset:  IM    
Université de Rennes 1, UPRES JE 2311, INSERM U835, Biochimie Pharmaceutique, 2, Avenue du Prof. Léon Bernard, 35043 Rennes, France.
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MeSH Terms
5' Untranslated Regions / genetics
Antiviral Agents / chemistry,  pharmacology*
Base Sequence
Cell Line
Cell-Free System
Hepacivirus / drug effects*
Imidazoles / chemistry,  pharmacology*
Oligodeoxyribonucleotides / chemistry,  pharmacology*
Oligodeoxyribonucleotides, Antisense / chemistry,  metabolism,  pharmacology*
RNA, Viral / chemistry,  drug effects*,  metabolism
Reg. No./Substance:
0/5' Untranslated Regions; 0/5' bis-imidazole AS-ODN; 0/Antiviral Agents; 0/Imidazoles; 0/Oligodeoxyribonucleotides; 0/Oligodeoxyribonucleotides, Antisense; 0/RNA, Viral; 288-32-4/imidazole

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