| Antiviral activity of the red marine alga Ceramium rubrum. | |
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MedLine Citation:
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PMID: 15287074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An extract from the red marine alga Ceramium rubrum (Huds.) Ag. from the Bulgarian Black Sea seacoast considerably inhibited the reproduction of influenza viruses type A and B in vitro and in ovo. The virus-induced cytopathogenic effect (CPE), infectious virus yields and the production of hemagglutinin were all reduced at non-toxic concentrations of the extract. The virus-inhibitory effect was selective, dose-related and strain-specific; selectivity indices ranged 9.5-68.3. The inhibition affected adsorption as well as the intracellular stages of viral replication. The extract inhibited also the reproduction of herpes simplex virus (HSV) type 1 and type 2 in cell cultures. The preparation exhibited a strong HSV-inactivating activity. |
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Authors:
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Julia Serkedjieva |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 18 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-08-02 Completed Date: 2004-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 480-3 Citation Subset: IM |
Affiliation:
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Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. jserkedjieva@microbio.bas.bg |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algae, Red* Animals Antiviral Agents / administration & dosage, pharmacology*, therapeutic use Cercopithecus aethiops Chick Embryo Chickens Herpes Simplex / prevention & control* Herpesvirus 1, Human / drug effects Herpesvirus 2, Human / drug effects Influenza A virus / drug effects Influenza B virus / drug effects Microbial Sensitivity Tests Orthomyxoviridae Infections / prevention & control* Phytotherapy* Plant Extracts / administration & dosage, pharmacology*, therapeutic use Vero Cells / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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