Document Detail


Antiviral activity of the interferon α family: biological and pharmacological aspects of the treatment of chronic hepatitis C.
MedLine Citation:
PMID:  23350850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Type I interferons (IFNs) comprise a group of at least 13 structurally related subtypes of IFN-α with similar, but not identical, biological activities. Each subtype displays a unique activity profile; only IFN-α2a and IFN-α2b subtypes together with natural IFN-α preparations are currently used in the clinical practice, so that the remaining IFN-α subtypes are a still unexploited reservoir of opportunity also in the new era of direct-acting antiviral agents for the treatment of hepatitis C virus (HCV).
AREAS COVERED: This paper reviews recent progress in the study of the biology of IFN family, the antiviral action mechanism and the strategies employed by HCV to evade IFN action. Currently available IFN preparations for the treatment of chronic hepatitis C infection are described and what is currently known on the pharmacokinetics, pharmacodynamics and immunogenicity of IFN-α preparations used in clinical practice are summarized.
EXPERT OPINION: The characterization of multifunctional nature of IFN system together with recent advances in the identification of HCV IFN evasion strategies and the variety of host factors influencing IFN treatment response should be considered to improve HCV and other infectious diseases treatment in the future.
Authors:
Carolina Scagnolari; Guido Antonelli
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-28
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  13     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-08     Completed Date:  2013-09-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-711     Citation Subset:  IM    
Affiliation:
Sapienza University, Department of Molecular Medicine, Laboratory of Virology, Viale di Porta Tiburtina n. 28, 00185 Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / immunology,  pharmacokinetics,  pharmacology*,  therapeutic use*
Hepatitis C, Chronic / drug therapy*,  immunology,  virology
Humans
Interferon-alpha / chemistry,  pharmacokinetics,  pharmacology*,  therapeutic use*
Receptors, Cell Surface / metabolism
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha; 0/Receptors, Cell Surface

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