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Antiviral activity of Distictella elongata (Vahl) Urb. (Bignoniaceae), a potentially useful source of anti-dengue drugs from the state of Minas Gerais, Brazil.
MedLine Citation:
PMID:  21895729     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aims:  To investigate the in vitro antiviral activity of Distictella elongata (Vahl) Urb. ethanol extracts from leaves (LEE), fruits (FEE), stems and its main components. Methods and Results:  The antiviral activity was evaluated against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), Vaccinia virus Western Reserve (VACV-WR) and Dengue virus 2 (DENV-2) by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. LEE presented anti-HSV-1 (EC(50) 142·8 ± 5·3 μg ml(-1) ; selectivity index (SI) 2·0) and anti-DENV-2 activity (EC(50) 9·8 ± 1·3 μg ml(-1) ; SI 1·5). The pectolinarin (1) isolated from LEE was less active against HSV-1 and DENV-2. A mixture of the triterpenoids ursolic, pomolic and oleanolic acids was also obtained. Ursolic and oleanolic acids have shown antiviral activity against HSV-1. A mixture of pectolinarin (1) and acacetin-7-O-rutinoside (2) was isolated from FEE and has presented anti-DENV-2 activity (EC(50) 11·1 ± 1·6 μg ml(-1) ; SI > 45). Besides the antiviral activity D. elongata has disclosed antioxidant effect. Conclusion:  These data shows that D. elongata have antiviral activity mainly against HSV-1 and DENV-2, besides antioxidant activity and it has been principally attributed to flavonoids isolated.
Authors:
L R Simões; G M Maciel; G C Brandão; E G Kroon; R O Castilho; A B Oliveira
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-5
Journal Detail:
Title:  Letters in applied microbiology     Volume:  -     ISSN:  1472-765X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510094     Medline TA:  Lett Appl Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 The Society for Applied Microbiology.
Affiliation:
Faculty of Pharmacy, Department of Pharmaceutical Products, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, CEP 31.270-901 Belo Horizonte, MG, Brazil Department of Microbiology, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, CEP 31.270-901 Belo Horizonte, MG, Brazil.
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