Document Detail

Antiviral activities of medicinal herbs traditionally used in southern mainland China.
MedLine Citation:
PMID:  15478204     Owner:  NLM     Status:  MEDLINE    
The aqueous extracts from 21 medicinal herbs traditionally used in southern mainland China were screened for antiviral activities against human herpes simplex virus type 1 (HSV-1) and human respiratory syncytial virus (RSV) using a cytopathic effect (CPE) reduction assay. Three extracts from Agrimonia pilosa, Pithecellobium clypearia and Punica granatum, respectively, showed anti-HSV-1 activity, which was possibly contributed by the polyphenolic compounds in the herbal extracts. Six of the extracts, from Blumea laciniata, Elephantopus scaber, Laggera pterodonta, Mussaenda pubescens, Schefflera octophylla and Scutellaria indica, respectively, exhibited anti-RSV activity with 50% inhibition (IC50) concentrations ranging from 12.5 to 32 microg/mL, and selective indices (SI) ranging from 11.2 to 40. In addition to polyphenolic compounds, other constituents present in these extracts may also contribute to their anti-RSV activity.
Yaolan Li; Linda S M Ooi; Hua Wang; Paul P H But; Vincent E C Ooi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  18     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  718-22     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 John Wiley & Sons, Ltd.
Department of Biology, The Chinese University of Hong Kong, Shatin, NT, People's Republic of China.
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MeSH Terms
Antiviral Agents / administration & dosage,  pharmacology*,  therapeutic use
Herpes Simplex / drug therapy
Herpesvirus 1, Human / drug effects*
Inhibitory Concentration 50
Medicine, Chinese Traditional
Microbial Sensitivity Tests
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Plants, Medicinal*
Reg. No./Substance:
0/Antiviral Agents; 0/Plant Extracts

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