| Antiviral Activity of Retrocyclin RC-101, a Candidate Microbicide Against Cell-Associated HIV-1. | |
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MedLine Citation:
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PMID: 22924614 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Microbicides have been evaluated mostly against cell-free HIV-1. Since semen contains both cell-free and cell-associated HIV-1, HIV-1 transmission could occur via either or both sources. Therefore, it is important to examine the antiviral activity of microbicides against cell-associated HIV-1. The cyclic antimicrobial peptide Retrocyclin RC-101 has been shown previously to have antiviral activity against cell-free HIV-1 with no associated cellular toxicity. In this report we have examined the antiviral activity of RC-101 against cell associated HIV-1. The results demonstrate potent antiviral activity of RC101 against cell-cell HIV-1 transmission in both CD4-dependent and CD4-independent assays against CCR5- and CXCR4-tropic HIV-1 with no cellular toxicity. Furthermore, this antiviral activity was retained in the presence of human seminal plasma. The potent antiviral activity of RC101 against cell- associated HIV-1 reported here, and the previously reported antiviral activity in cervical tissues suggest that RC-101 is excellent promising microbicide candidate against HIV-1. |
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Authors:
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Phalguni Gupta; Carol Lackman-Smith; Beth Snyder; Deena Ratner; Lisa Rohan; Dorothy Patton; Bharat Ramratnam; Alexander Cole |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-27 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Pittsburgh, Infectious Diseases and Microbiology, 130 Desoto Street, Pittsburgh, Pennsylvania, United States, 15261, 412-624-7998, 412-624-4953; pgupta1@pitt.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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