Document Detail


Antiviral activity of retrocyclin RC-101, a candidate microbicide against cell-associated HIV-1.
MedLine Citation:
PMID:  22924614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microbicides have been evaluated mostly against cell-free HIV-1. Because semen contains both cell-free and cell-associated HIV-1, HIV-1 transmission could occur via either or both sources. Therefore, it is important to examine the antiviral activity of microbicides against cell-associated HIV-1. The cyclic antimicrobial peptide retrocyclin RC-101 has been shown previously to have antiviral activity against cell-free HIV-1, with no associated cellular toxicity. In this article we have examined the antiviral activity of RC-101 against cell-associated HIV-1. The results demonstrate potent antiviral activity of RC-101 against cell-cell HIV-1 transmission in both CD4-dependent and CD4-independent assays against CCR5- and CXCR4-tropic HIV-1, with no cellular toxicity. Furthermore, this antiviral activity was retained in the presence of human seminal plasma. The potent antiviral activity of RC-101 against cell-associated HIV-1 reported here, and the previously reported antiviral activity in cervical tissues, suggest that RC-101 is an excellent and promising microbicide candidate against HIV-1.
Authors:
Phalguni Gupta; Carol Lackman-Smith; Beth Snyder; Deena Ratner; Lisa C Rohan; Dorothy Patton; Bharat Ramratnam; Alexander M Cole
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-10
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-22     Completed Date:  2013-07-01     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / pharmacology*
Cells, Cultured
Defensins / pharmacology*
HIV-1 / drug effects*
Humans
Microbial Sensitivity Tests
Peptides / pharmacology*
Grant Support
ID/Acronym/Agency:
U19 AI65430/AI/NIAID NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Defensins; 0/Peptides; 0/RC 101; 0/theta-defensin
Comments/Corrections

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