Document Detail

Antiviral Activity of Methylelaiophylin, an alpha-Glucosidase Inhibitor.
MedLine Citation:
PMID:  21464596     Owner:  NLM     Status:  In-Data-Review    
Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an alpha-glucosidase inhibitor with an IC50 value of 10 micrometer. It showed mixedtype inhibition of alpha-glucosidase with a Ki value of 5.94 micrometer. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
Doseung Lee; Jin-Kyu Woo; Donghern Kim; Minyoung Kim; Somi K Cho; Jae Hoon Kim; Se Pill Park; Hyo Yeon Lee; Key Zung Riu; Dong-Sun Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microbiology and biotechnology     Volume:  21     ISSN:  1738-8872     ISO Abbreviation:  J. Microbiol. Biotechnol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431852     Medline TA:  J Microbiol Biotechnol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  263-6     Citation Subset:  IM    
Faculty of Biotechnology, College of Applied Life Science, Jeju National University, Jeju 690-756, Korea , Subtropical Horticulture Research Institute, Jeju National University, Jeju 690-756, Korea.
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