| Antiviral Activity of Methylelaiophylin, an alpha-Glucosidase Inhibitor. | |
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MedLine Citation:
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PMID: 21464596 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an alpha-glucosidase inhibitor with an IC50 value of 10 micrometer. It showed mixedtype inhibition of alpha-glucosidase with a Ki value of 5.94 micrometer. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells. |
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Authors:
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Doseung Lee; Jin-Kyu Woo; Donghern Kim; Minyoung Kim; Somi K Cho; Jae Hoon Kim; Se Pill Park; Hyo Yeon Lee; Key Zung Riu; Dong-Sun Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of microbiology and biotechnology Volume: 21 ISSN: 1738-8872 ISO Abbreviation: J. Microbiol. Biotechnol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431852 Medline TA: J Microbiol Biotechnol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 263-6 Citation Subset: IM |
Affiliation:
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Faculty of Biotechnology, College of Applied Life Science, Jeju National University, Jeju 690-756, Korea , Subtropical Horticulture Research Institute, Jeju National University, Jeju 690-756, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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