| Antivascular cancer treatments: functional assessments by dynamic contrast-enhanced magnetic resonance imaging. | |
| | |
MedLine Citation:
|
PMID: 15688112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
New anticancer therapeutics that target tumor blood vessels promise improved efficacy and tolerability in humans. Early phase 1 drug trials have shown that the maximum tolerated dose may be inappropriate for more advanced clinical studies with efficacy endpoints. More advanced clinical trials have demonstrated that morphologic assessments of tumor response are of limited value for gauging the efficacy of treatment. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can serve as pharmacodynamic indicator of biological activity for antivascular cancer drugs by helping to define the biologically active dose. DCE-MRI studies may also predict the efficacy of treatment on the basis of changes observed. If DCE-MRI is to be used for the selection of antivascular drugs that advance into efficacy trials, then it will be necessary to develop standardized approaches to measurement and robust analytic approaches with clear accepted endpoints specified prospectively that have biological validity. Such developments will be essential for multicenter trials in which it will be necessary to establish effective cross-site standardization of measurements and evaluation. |
| | |
Authors:
|
A R Padhani; M O Leach |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Abdominal imaging Volume: 30 ISSN: 0942-8925 ISO Abbreviation: Abdom Imaging Publication Date: 2005 May-Jun |
Date Detail:
|
Created Date: 2005-06-20 Completed Date: 2005-09-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9303672 Medline TA: Abdom Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 324-41 Citation Subset: IM |
Affiliation:
|
Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex HA6 2RN, United Kingdom. anwar.padhani@paulstrickland-scannercentre.org.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiogenesis Inhibitors
/
therapeutic use* Antineoplastic Agents / therapeutic use* Contrast Media / pharmacokinetics Gadolinium DTPA / diagnostic use Humans Image Enhancement Magnetic Resonance Imaging / methods* Neoplasms / diagnosis, drug therapy* Neovascularization, Pathologic / drug therapy, physiopathology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Angiogenesis Inhibitors; 0/Antineoplastic Agents; 0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Short-term complications of retrograde transvenous obliteration of gastric varices in patients with ...
Next Document: Complications of radiofrequency ablation in hepatocellular carcinoma.