Document Detail


Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system.
MedLine Citation:
PMID:  20420892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Achillea millefolium L. is a member of the Asteraceae family that is commonly referred to as "yarrow" and has been used in folk medicine against several disturbances including skin inflammations, spasmodic and gastrointestinal disorders, as well as hepato-biliary complaints. AIM OF THE STUDY: In the present study, we evaluated the efficacy of a hydroalcoholic extract from the Achillea millefolium (HE) for gastroprotective properties and additional mechanism(s) involved in this activity. MATERIAL AND METHODS: Rats were treated with HE and subsequently exposed to both acute gastric lesions induced by ethanol P.A. and chronic gastric ulcers induced by 80% acetic acid. Following treatment, glutathione (GSH) levels and superoxide dismutase (SOD) activity were measured. The activity of myeloperoxidase (MPO) and histological and immunohistochemical analysis were performed in animals with acetic acid-induced gastric ulcers. RESULTS: Oral administration of HE (30, 100 and 300mg/kg) inhibited ethanol-induced gastric lesions by 35, 56 and 81%, respectively. Oral treatment with HE (1 and 10mg/kg) reduced the chronic gastric ulcers induced by acetic acid by 43 and 65%, respectively, and promoted significant regeneration of the gastric mucosa after ulcer induction denoting increased cell proliferation, which was confirmed by PCNA immunohistochemistry. HE treatment prevented the reduction of GSH levels and SOD activity after acetic acid-induced gastric lesions. In addition, HE (10mg/kg) inhibited the MPO activity in acetic acid-induced gastric ulcers. CONCLUSIONS: The results of the present study indicate that the antioxidant properties of HE may contribute to the gastroprotective activity of this extract.
Authors:
Francine Bittencourt Potrich; Alexandra Allemand; Luísa Mota da Silva; Ana Cristina Dos Santos; Cristiane Hatsuko Baggio; Cristina Setim Freitas; Daniel Augusto Gasparin Bueno Mendes; Eunice Andre; Maria Fernanda de Paula Werner; Maria Consuelo Andrade Marques
Publication Detail:
Type:  Journal Article     Date:  2010-04-24
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  130     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Pharmacology, Universidade Federal do Paraná, Curitiba, PR, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Achillea / chemistry*
Animals
Anti-Ulcer Agents / pharmacology*
Antioxidants / pharmacology*
Dose-Response Relationship, Drug
Ethanol / chemistry*
Female
Glutathione / metabolism
Immunohistochemistry
Peroxidase / metabolism
Plant Extracts / pharmacology*
Rats
Rats, Wistar
Stomach Ulcer / prevention & control
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Antioxidants; 0/Plant Extracts; 64-17-5/Ethanol; 70-18-8/Glutathione; EC 1.11.1.7/Peroxidase; EC 1.15.1.1/Superoxide Dismutase

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