| Antiulcer activity of Sapindus saponaria L. in the rat. | |
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MedLine Citation:
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PMID: 12169404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracts of leaves and fruits of Sapindus saponaria L. were orally administered to rats and the parameters of gastric secretion (volume, pH and acidity) were evaluated after pylorus ligature. The inhibitory effect of the extracts on lesions induced by stress was compared to that of cimetidine. The volume and concentration of hydrochloric acid were reduced after oral administration of the extracts. A significant reduction of the lesion index was observed in the acute assays. No significant alteration in body or organ weight was detected in animals treated orally for 30 days with the extracts. These results suggest that S. saponaria fruits have an anti-gastric ulcer potential. |
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Authors:
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Adriana L Meyer Albiero; Jayme Antonio Aboin Sertié; Elfriede Marianne Bacchi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 82 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-08-09 Completed Date: 2003-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
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Department of Pharmacy and Pharmacology, Universidade Estadual de Maringá, PR Avenida Colombo, 5790 CEP 87020-900, Maringá, PR, Brazil. almaalbiero@uem.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Ulcer Agents / therapeutic use*, toxicity Dose-Response Relationship, Drug Ethanol Female Gastric Acid / secretion Organ Size Phytotherapy* Plant Extracts / therapeutic use, toxicity Rats Rats, Wistar Sapindus* Stomach / drug effects, pathology Stomach Ulcer / drug therapy*, pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Plant Extracts; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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