Document Detail

Antiulcer activity of Sapindus saponaria L. in the rat.
MedLine Citation:
PMID:  12169404     Owner:  NLM     Status:  MEDLINE    
Extracts of leaves and fruits of Sapindus saponaria L. were orally administered to rats and the parameters of gastric secretion (volume, pH and acidity) were evaluated after pylorus ligature. The inhibitory effect of the extracts on lesions induced by stress was compared to that of cimetidine. The volume and concentration of hydrochloric acid were reduced after oral administration of the extracts. A significant reduction of the lesion index was observed in the acute assays. No significant alteration in body or organ weight was detected in animals treated orally for 30 days with the extracts. These results suggest that S. saponaria fruits have an anti-gastric ulcer potential.
Adriana L Meyer Albiero; Jayme Antonio Aboin Sertié; Elfriede Marianne Bacchi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  82     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-09     Completed Date:  2003-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ireland Ltd.
Department of Pharmacy and Pharmacology, Universidade Estadual de Maringá, PR Avenida Colombo, 5790 CEP 87020-900, Maringá, PR, Brazil.
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MeSH Terms
Administration, Oral
Anti-Ulcer Agents / therapeutic use*,  toxicity
Dose-Response Relationship, Drug
Gastric Acid / secretion
Organ Size
Plant Extracts / therapeutic use,  toxicity
Rats, Wistar
Stomach / drug effects,  pathology
Stomach Ulcer / drug therapy*,  pathology,  physiopathology
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Plant Extracts; 64-17-5/Ethanol

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