Document Detail

Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines.
MedLine Citation:
PMID:  10462079     Owner:  NLM     Status:  MEDLINE    
The antiproliferative effects of squamocin, one of the easiest annonaceous acetogenins to obtain, were studied in the parental (MCF7-S) and the multidrug resistant (MCF7-R) human breast adenocarcinoma cell lines. Squamocin inhibited proliferation of both cell lines identically, by blocking the cell cycle in the G1-phase. This inhibition was reversible in the long term. Squamocin decreased the ATP pool in both MCF7 cell lines, but did not seem to induce apoptosis. Cytotoxic activity of adriamycin was not restored in MCF7-R Pgp expressing cells by squamocin addition.
S Raynaud; F Némati; L Miccoli; P Michel; M F Poupon; C Fourneau; A Laurens; R Hocquemiller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  65     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1999  
Date Detail:
Created Date:  1999-09-08     Completed Date:  1999-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-33     Citation Subset:  IM    
Laboratoire de Pharmacognosie, URA CNRS 1843 (BIOCIS), Faculté de Pharmacie, Université de Paris XI, Châtenay-Malabry, France.
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MeSH Terms
Adenocarcinoma / drug therapy*,  pathology
Antibiotics, Antineoplastic / pharmacology,  therapeutic use
Antineoplastic Agents, Phytogenic / pharmacology*,  therapeutic use
Apoptosis / drug effects
Breast Neoplasms / drug therapy*,  pathology
Cell Division / drug effects
Dose-Response Relationship, Drug
Doxorubicin / pharmacology,  therapeutic use
Drug Resistance, Multiple
Furans / pharmacology*,  therapeutic use
G1 Phase / drug effects
Lactones / pharmacology*,  therapeutic use
Tumor Cells, Cultured
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents, Phytogenic; 0/Furans; 0/Lactones; 120298-30-8/squamocin; 23214-92-8/Doxorubicin

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