| Antitumoral effects of squamocin on parental and multidrug resistant MCF7 (human breast adenocarcinoma) cell lines. | |
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MedLine Citation:
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PMID: 10462079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiproliferative effects of squamocin, one of the easiest annonaceous acetogenins to obtain, were studied in the parental (MCF7-S) and the multidrug resistant (MCF7-R) human breast adenocarcinoma cell lines. Squamocin inhibited proliferation of both cell lines identically, by blocking the cell cycle in the G1-phase. This inhibition was reversible in the long term. Squamocin decreased the ATP pool in both MCF7 cell lines, but did not seem to induce apoptosis. Cytotoxic activity of adriamycin was not restored in MCF7-R Pgp expressing cells by squamocin addition. |
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Authors:
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S Raynaud; F Némati; L Miccoli; P Michel; M F Poupon; C Fourneau; A Laurens; R Hocquemiller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 65 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-09-08 Completed Date: 1999-09-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 525-33 Citation Subset: IM |
Affiliation:
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Laboratoire de Pharmacognosie, URA CNRS 1843 (BIOCIS), Faculté de Pharmacie, Université de Paris XI, Châtenay-Malabry, France. reynald.hocquemiller@cep.u-psud.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy*,
pathology Antibiotics, Antineoplastic / pharmacology, therapeutic use Antineoplastic Agents, Phytogenic / pharmacology*, therapeutic use Apoptosis / drug effects Breast Neoplasms / drug therapy*, pathology Cell Division / drug effects Dose-Response Relationship, Drug Doxorubicin / pharmacology, therapeutic use Drug Resistance, Multiple Female Furans / pharmacology*, therapeutic use G1 Phase / drug effects Humans Lactones / pharmacology*, therapeutic use Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents, Phytogenic; 0/Furans; 0/Lactones; 120298-30-8/squamocin; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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