Document Detail

Antitumoral action of 2-deoxy-D-glucose tetraacetate in human melanoma cells.
MedLine Citation:
PMID:  10948345     Owner:  NLM     Status:  MEDLINE    
The ester 2-deoxy-D-glucose tetraacetate (2-DOGTA) was recently shown to display cytostatic and cytotoxic activity in various lines of tumoral cells. In the present work, it was found to inhibit cell growth and confer chemosensitivity to cisplatin in two lines of human melanoma cells, poorly responsive to cisplatin. The inhibition of cell growth by 2-DOGTA was apparently not attributable to alteration of either D-glucose utilization or oxidation in these melanoma cell lines. In freshly isolated human melanoma cells, 2-DOGTA also inhibited cell growth, even in cells resistant to standard chemotherapeutic agents, such as temozolomide, cisplatin and/or vindesine. It is proposed, therefore, that 2-DOGTA should be further investigated for the treatment of melanoma patients, whether alone or in combination with known chemotherapeutic agents.
U Reinhold; S Ugurel; W Tilgen; M M Kadiata; E Olivares; A B Nadi; W J Malaisse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncology reports     Volume:  7     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2000-08-24     Completed Date:  2001-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1093-7     Citation Subset:  IM    
Department of Dermatology, The Saarland University Hospital, D-66421 Homburg/Saar, Germany.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Antineoplastic Combined Chemotherapy Protocols / pharmacology
Cell Division / drug effects
Cisplatin / administration & dosage,  pharmacology
Dacarbazine / analogs & derivatives*,  pharmacology
Drug Screening Assays, Antitumor
Glucose / administration & dosage,  metabolism,  pharmacology*
Melanoma / drug therapy*,  metabolism,  pathology
Middle Aged
Tumor Cells, Cultured
Vindesine / pharmacology
Reg. No./Substance:
0/2-deoxy-glucose tetraacetate; 0/Antineoplastic Agents; 15663-27-1/Cisplatin; 4342-03-4/Dacarbazine; 50-99-7/Glucose; 53643-48-4/Vindesine; 85622-93-1/temozolomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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