| Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus. | |
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MedLine Citation:
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PMID: 22840014 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-α. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity. |
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Authors:
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Liuping Fan; Shaodong Ding; Lianzhong Ai; Kequan Deng |
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Publication Detail:
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Type: Journal Article Date: 2012-06-17 |
Journal Detail:
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Title: Carbohydrate polymers Volume: 90 ISSN: 1879-1344 ISO Abbreviation: Carbohydr Polym Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-07-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307156 Medline TA: Carbohydr Polym Country: England |
Other Details:
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Languages: eng Pagination: 870-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy & Food Co. Ltd., Shanghai 200436, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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