Document Detail


Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus.
MedLine Citation:
PMID:  22840014     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The medicinal mushroom Inonotus obliquus has been used as a folk remedy for a long time in Russia and East-European countries to treat gastrointestinal cancer, cardiovascular disease and diabetes. In our study, a water-soluble polysaccharide (ISP2a) was successfully purified from I. obliquus by DEAE-Sepharose CL-6B and Sepharose CL-6B column chromatography. In vivo ISP2a had not only shown antitumor activity, but also could significantly enhance the immune response of tumor-bearing mice. In addition, ISP2a significantly enhanced the lymphocyte proliferation and increased the production of TNF-α. Results of these studies demonstrated that ISP2a had a potential application as natural antitumor agent with immunomodulatory activity.
Authors:
Liuping Fan; Shaodong Ding; Lianzhong Ai; Kequan Deng
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Publication Detail:
Type:  Journal Article     Date:  2012-06-17
Journal Detail:
Title:  Carbohydrate polymers     Volume:  90     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  870-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy & Food Co. Ltd., Shanghai 200436, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
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