| Antitumor efficacy of poly(dimer acid-dodecanedioic acid) copolymer in mice bearing Sarcoma-180 tumor. | |
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MedLine Citation:
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PMID: 17387591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The drug release profiles of poly(dimer acid-dodecanedioic acid) P(DA-DDDA) copolymer containing 5% adriamycin hydrochloride (ADM) in vitro were evaluated. The biocompatibility of P(DA-DDDA) under mice skin was also evaluated, macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. Antitumor efficacy of P(DA-DDDA) copolymers containing 5% adriamycin hydrochloride (ADM) implanted subcutaneously in mice bearing Sarcoma-180 tumor exhibited increased volume doubling time (VDT) (31 +/- 1.5 days) compared to plain subcutaneous injection of ADM (7 +/- 0.9 days). The studies suggest that P(DA-DDDA) copolymer as an effective carrier for antineoplastic drug like adriamycin hydrochloride has a very good prospect in the treatment of noumenon tumors. |
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Authors:
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Wen-Xun Guo; Zongli Shi; Fan-Bing Zeng; Kui Liang; Xian-Hong Chen; Yong-Ping Ai; Min Fang; Xiao Sun; Zhi Zhang; Li-Xin Hu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-27 |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 18 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-04 Completed Date: 2007-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 1515-20 Citation Subset: IM |
Affiliation:
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College of Materials Science and Engineering, Hunan University, Changsha, Hunan 410082, P.R. China. guowenxun@126.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibiotics, Antineoplastic / administration & dosage*, chemistry, pharmacokinetics Cell Line, Tumor Cell Survival / drug effects Delayed-Action Preparations / administration & dosage*, chemistry, pharmacokinetics Dicarboxylic Acids / administration & dosage*, chemistry, pharmacokinetics Diffusion Doxorubicin / administration & dosage*, chemistry, pharmacokinetics Drug Compounding / methods Drug Implants Injections, Subcutaneous Materials Testing Mice Polymers / administration & dosage*, chemistry, pharmacokinetics Sarcoma / drug therapy*, pathology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Delayed-Action Preparations; 0/Dicarboxylic Acids; 0/Drug Implants; 0/Polymers; 0/poly(dimer acid-dodecanedioic acid) copolymer; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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