Document Detail


Antitumor effects of two novel naturally occurring terpene quinones isolated from the Mediterranean ascidian Aplidium conicum.
MedLine Citation:
PMID:  15857147     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ascidian Aplidium conicum collected along Sardinia coasts (Italy) contained two novel prenylated benzoquinones, designated thiaplidiaquinone A (1) and thiaplidiaquinone B (2). These compounds showed an unprecedented tetracyclic structure. We have studied the pro-apototic mechanisms of both prenylated benzoquinones in the Jurkat cell line that is derived from a human T lymphoma, and we show that both compounds induce a strong production of intracellular reactive oxygen species (ROS) in this cell line. Moreover, kinetic experiments, comparing the timing of ROS induction with the collapse of the mitochondria potential (DeltaPsi(m)), clearly showed that ROS preceded the disruption of the mitochondrial potential, and the later one paralleled the appearance of apoptotic cells. Thus, thiaplidiaquinones A and B can enter into the cells and induce cell death by apoptosis.
Authors:
Anna Aiello; Ernesto Fattorusso; Paolo Luciano; Antonio Macho; Marialuisa Menna; Eduardo Muñoz
Related Documents :
18068747 - Study of cell killing effect on s180 by ultrasound activating protoporphyrin ix.
10092527 - Altered levels of primary antioxidant enzymes in progeria skin fibroblasts.
15857147 - Antitumor effects of two novel naturally occurring terpene quinones isolated from the m...
19194067 - Intervention of oxygen-control ability to radiation sensitivity, cell aging and cell tr...
3943557 - Biochemical characterization of the cholesterol-dependent growth of the ns-1 mouse myel...
19003017 - Effect of the water extracts of propolis on stimulation and inhibition of different cells.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  48     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-28     Completed Date:  2005-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3410-6     Citation Subset:  IM    
Affiliation:
Dipartimento di Chimica delle Sostanze Naturali, Universitá degli Studi di Napoli Federico II, Via Domenico Montesano n. 49-80131, Napoli, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / isolation & purification,  pharmacology*
Apoptosis
Benzoquinones / isolation & purification,  pharmacology*
Humans
Jurkat Cells
Kinetics
Magnetic Resonance Spectroscopy
Membrane Potentials / drug effects
Mitochondria / drug effects,  physiology
Reactive Oxygen Species / metabolism
Terpenes / isolation & purification,  pharmacology*
Thiazines / isolation & purification,  pharmacology*
Urochordata / chemistry*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzoquinones; 0/Reactive Oxygen Species; 0/Terpenes; 0/Thiazines; 0/thiaplidiaquinone A; 0/thiaplidiaquinone B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinas...
Next Document:  Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones.