Document Detail

Antitumor effects of two novel naturally occurring terpene quinones isolated from the Mediterranean ascidian Aplidium conicum.
MedLine Citation:
PMID:  15857147     Owner:  NLM     Status:  MEDLINE    
The ascidian Aplidium conicum collected along Sardinia coasts (Italy) contained two novel prenylated benzoquinones, designated thiaplidiaquinone A (1) and thiaplidiaquinone B (2). These compounds showed an unprecedented tetracyclic structure. We have studied the pro-apototic mechanisms of both prenylated benzoquinones in the Jurkat cell line that is derived from a human T lymphoma, and we show that both compounds induce a strong production of intracellular reactive oxygen species (ROS) in this cell line. Moreover, kinetic experiments, comparing the timing of ROS induction with the collapse of the mitochondria potential (DeltaPsi(m)), clearly showed that ROS preceded the disruption of the mitochondrial potential, and the later one paralleled the appearance of apoptotic cells. Thus, thiaplidiaquinones A and B can enter into the cells and induce cell death by apoptosis.
Anna Aiello; Ernesto Fattorusso; Paolo Luciano; Antonio Macho; Marialuisa Menna; Eduardo Muñoz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  48     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-28     Completed Date:  2005-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3410-6     Citation Subset:  IM    
Dipartimento di Chimica delle Sostanze Naturali, Universitá degli Studi di Napoli Federico II, Via Domenico Montesano n. 49-80131, Napoli, Italy.
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MeSH Terms
Antineoplastic Agents / isolation & purification,  pharmacology*
Benzoquinones / isolation & purification,  pharmacology*
Jurkat Cells
Magnetic Resonance Spectroscopy
Membrane Potentials / drug effects
Mitochondria / drug effects,  physiology
Reactive Oxygen Species / metabolism
Terpenes / isolation & purification,  pharmacology*
Thiazines / isolation & purification,  pharmacology*
Urochordata / chemistry*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzoquinones; 0/Reactive Oxygen Species; 0/Terpenes; 0/Thiazines; 0/thiaplidiaquinone A; 0/thiaplidiaquinone B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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