Document Detail


Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells.
MedLine Citation:
PMID:  19926245     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Polymer nanoparticles have become attractive for its prominent property recent years. In this paper, antitumor effects of N-succinyl-chitosan nanoparticles (NSCNP), a nanoparticles derivated from chitosan, were evaluated in K562 cells, including cell viability comparison, cell morphology analysis, DNA fragmentation detection, cell surface potential and mitochondrial membrane potential (MMP) measurement, intracellular ROS and Ca(2+) concentration evaluation. Our results revealed NSCNP could inhibit the proliferation of K562 with an IC(50) of 14.26 μg/ml (24h); decrease the zeta potential; disrupt the mitochondrial membrane potential; increase ROS generation and Ca(2+) concentration. Cytomorphology study and DNA fragment analysis reveal characteristics of apoptosis and necrosis, indicating that the antitumor effect of NSCNP achieved by necrosis and apoptosis induction in K562 cells.
Authors:
Huiying Luo; Juan Li; Xuan Chen
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Publication Detail:
Type:  Journal Article     Date:  2009-10-28
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  64     ISSN:  1950-6007     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  521-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Masson SAS. All rights reserved.
Affiliation:
Department of Pharmacology, Gansu College of Traditional Chinese Medicine, No. 35, Dingxi East Road, Lanzhou 730000, PR China. louria@vip.sina.com
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