| Antitumor carbazoles. | |
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MedLine Citation:
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PMID: 17348830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural and synthetic carbazoles, either in a pure substituted or in an annellated substituted form, represent an important and heterogeneous class of anticancer agents, which has grown considerably over the last two decades. Many carbazole derivatives have been tested for cyctotoxic activity, some of them have entered clinical trials, but only very few have been approved for the treatment of cancer so far, since the clinical application of many carbazoles has encountered problems like severe side effects or multidrug resistance. Due to their polycyclic, planar and aromatic structure carbazoles are predestined for intercalation into DNA and therefore DNA remains one of the main targets for cytotoxic carbazoles. For many carbazoles cytotoxicity can be related to DNA-dependent enzyme inhibition such as topoisomerase I/II and telomerase. But also other targets such as cyclin-dependent kinases and estrogen receptors have emerged. |
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Authors:
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Christian Asche; Martine Demeunynck |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Anti-cancer agents in medicinal chemistry Volume: 7 ISSN: 1871-5206 ISO Abbreviation: - Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265649 Medline TA: Anticancer Agents Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 247-67 Citation Subset: IM |
Affiliation:
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LEDSS, CNRS UMR 5616 & ICMG-FR2607, Université Joseph Fourier, BP 53, 38041 Grenoble Cédex 9, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis*, chemistry, pharmacology* Carbazoles / chemical synthesis*, chemistry, pharmacology* DNA, Neoplasm / drug effects Humans Intercalating Agents / chemical synthesis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Carbazoles; 0/DNA, Neoplasm; 0/Intercalating Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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