Document Detail

Antitumor activity of polymorphonuclear leukocytes activated by a beta-1,3-D-glucan.
MedLine Citation:
PMID:  1779406     Owner:  NLM     Status:  MEDLINE    
The antitumor activity of mouse polymorphonuclear leukocyte (PMN) treated with a beta-1,3-D-glucan from Alcaligenes faecalis var. myxogenes IFO 13140 (TAK-N) and its carboxymethylated derivative (CM-TAK) was investigated in vitro and in vivo. ICR mouse PMN showed strong cytotoxicity against sarcoma 180 cells and inhibition of the growth of the tumor cells in vitro in the presence of TAK-N but not in the presence of CM-TAK. Since the cytotoxicity induced by TAK-N was almost completely inhibited by catalase, it seems to be mediated by H2O2 production by PMN. On the other hand, TAK-N induced no cytotoxicity in macrophages and neither did CM-TAK in PMN or in macrophage. Intraperitoneal injection of TAK-N into ICR mice induced a large number of PMN and macrophages in the peritoneal cavity. The peritoneal exudate PMN which were harvested at 10 to 72 h after TAK-N injection showed cytotoxicity against sarcoma 180 cells, but the peritoneal exudate macrophages did not. Treatment of sarcoma 180 ascites tumor-bearing ICR mice with TAK-N at a dose of 100 mg/kg prolonged significantly the survival time over that of the control. These results indicate that TAK-N induces PMN cytotoxicity against sarcoma 180 cells not only in vitro but also in vivo. The antitumor effect of TAK-N on sarcoma 180 ascites tumor seems to be derived from PMN stimulated with TAK-N.
S Kasai; S Fujimoto; K Nitta; H Baba; T Kunimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  14     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-03-10     Completed Date:  1992-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Chemotherapy Division, Chiba Cancer Center Research Institute, Japan.
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MeSH Terms
Cytotoxicity, Immunologic / drug effects*
Free Radical Scavengers
Glucans / pharmacology*
Macrophages / drug effects,  immunology
Mice, Inbred ICR
Neoplasms, Experimental / immunology*
Neutrophils / drug effects*,  immunology
Sarcoma 180 / prevention & control
Reg. No./Substance:
0/Free Radical Scavengers; 0/Glucans; 0/beta-Glucans; 9051-97-2/beta-1,3-glucan

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