| Antitumor activity of a new series of platinum complexes: trans(+/-)-1,2-cyclohexanediammineplatinum(II) conjugated to acid polysaccharides. | |
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MedLine Citation:
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PMID: 8490195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Complexes with trans(+/-)-1,2-cyclohexanediammineplatinum(II) conjugated to acid polysaccharides were synthesized and their antitumor activities were tested in female CDF1 mice with intraperitoneal leukemia L1210 cells. Platinum was released from the polymers under physiological conditions, with half-lives from 3.3 to 19.3 h. A hyaluronic acid-supported complex was the most effective against the tumors (all six mice survived for 60 days). The group given a chondroitin polysulfate-supported complex had five survivors, the chondroitin sulfate A group also had five, the chondroitin sulfate C group had three and the heparan sulfate group had two. Part of the antitumor activity was due to increased efficacy of the polymers. The bioavailability of these complexes is high. Therefore, acid polysaccharides should be a good system for delivering antitumor platinum complexes. |
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Authors:
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M Maeda; N Takasuka; T Suga; N Uehara; A Hoshi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anti-cancer drugs Volume: 4 ISSN: 0959-4973 ISO Abbreviation: Anticancer Drugs Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-06-16 Completed Date: 1993-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100823 Medline TA: Anticancer Drugs Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 167-71 Citation Subset: IM |
Affiliation:
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Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chondroitin Sulfates / chemical synthesis, pharmacology Cisplatin / chemical synthesis, pharmacokinetics, pharmacology* Drug Screening Assays, Antitumor Female Half-Life Leukemia L1210 / drug therapy Mice Mice, Inbred Strains Platinum / blood Polysaccharides / chemical synthesis, pharmacokinetics, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Polysaccharides; 15663-27-1/Cisplatin; 7440-06-4/Platinum; 9007-28-7/Chondroitin Sulfates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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