| Antitumor activity of a new amino acid derivative, N6,N9-bis-(butyloxycarbonylaminomethyl)-L-citrulline. | |
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MedLine Citation:
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PMID: 205478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Approximately 800 amino acid derivatives have been synthesized and screened in order to evaluate their antitumor activity against various transplantable rat ascites hepatomas. Among them, N6,N9-bis(butyloxycarbonylaminomethyl)-L-citrulline (A-924) was found to be highly effective against various rat ascites hepatomas. A-924, when given orally, exhibited prolongation of survival of rats implanted intravenously with ascites hepatoma cells such as AH-44, AH-66, AH-130, AH-66F, or AH-41C. |
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Authors:
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H Fujita; Y Seto; T Sakurai; H Ichimura; H Satoh; S Toyoshima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gann = Gan Volume: 69 ISSN: 0016-450X ISO Abbreviation: Gann Publication Date: 1978 Feb |
Date Detail:
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Created Date: 1978-06-12 Completed Date: 1978-06-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8214471 Medline TA: Gann Country: JAPAN |
Other Details:
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Languages: eng Pagination: 99-101 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Carcinoma, Hepatocellular / drug therapy* Citrulline / administration & dosage, analogs & derivatives*, therapeutic use Liver Neoplasms Male Neoplasms, Experimental / drug therapy Rats |
| Chemical | |
Reg. No./Substance:
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372-75-8/Citrulline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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