Document Detail

Antitumor activity of equinatoxin.
MedLine Citation:
PMID:  5194     Owner:  NLM     Status:  MEDLINE    
Equinatoxin, a highly basic protein extracted from Actinia equina, causes an increase in the survival time of mice bearing the ascitic form of Ehrlich carcinoma, whereas it has no effect on L1210 leukaemia. When tested for in vitro cytotoxicity by the dye exclusion test, it shows a potent activity on both tumour cell lines, with ED50 of a few ng/ml. Higher concentrations produce an extensive lysis of the cells. The cytotoxic effects of Equinatoxin are inhibited by phospholipids, thus suggesting that its mechanism of action may be related to interactions with lipids or other charged components of cell membrane. The observed lack of in vivo activity against L1210 leukaemia presumably is due to poor systemic absorption of the protein and/or neutralization by serum factors.
T Giraldi; I Ferlan; D Romeo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  13     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents*
Carcinoma, Ehrlich Tumor / drug therapy*
Cell Survival / drug effects
Dose-Response Relationship, Drug
Leukemia L1210 / drug therapy*
Proteins / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Proteins

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