Document Detail


Antitumor activity of equinatoxin.
MedLine Citation:
PMID:  5194     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Equinatoxin, a highly basic protein extracted from Actinia equina, causes an increase in the survival time of mice bearing the ascitic form of Ehrlich carcinoma, whereas it has no effect on L1210 leukaemia. When tested for in vitro cytotoxicity by the dye exclusion test, it shows a potent activity on both tumour cell lines, with ED50 of a few ng/ml. Higher concentrations produce an extensive lysis of the cells. The cytotoxic effects of Equinatoxin are inhibited by phospholipids, thus suggesting that its mechanism of action may be related to interactions with lipids or other charged components of cell membrane. The observed lack of in vivo activity against L1210 leukaemia presumably is due to poor systemic absorption of the protein and/or neutralization by serum factors.
Authors:
T Giraldi; I Ferlan; D Romeo
Related Documents :
20689764 - Effect of ovarian cancer ascites on cell migration and gene expression in an epithelial...
2074264 - Ehrlich ascites tumour cells show tissue-specific adherence and modify their shape upon...
9868804 - Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyan...
1911884 - Reduced growth of ehrlich ascites tumor cells in creatine depleted mice fed beta-guanid...
21372494 - Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas ...
7521444 - Visualization of binding and uptake of oxidized low density lipoproteins by cultured me...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  13     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents*
Carcinoma, Ehrlich Tumor / drug therapy*
Cell Survival / drug effects
Cnidaria
Dose-Response Relationship, Drug
Leukemia L1210 / drug therapy*
Male
Mice
Proteins / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Xylanase (hemicellulase) activity in cell-free rumen fluid.
Next Document:  [Effect of ionic strength on the protection of DNA by histone F1 against the enzymatic activity of D...