| Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma. | |
| | |
MedLine Citation:
|
PMID: 20967867 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: The antitumor effect of enzastaurin, a specific protein kinase C beta (PKC-β) inhibitor, was tested on head and neck squamous cell carcinoma (HNSCC) cell lines, as well as HNSCC xenograft model. METHODS: HNSCC cell lines and xenograft were treated with enzastaurin alone or in combination with radiation to evaluate its antitumor effect. Annexin V-FITC staining and Western blot were done to analyze enzastaurin-induced changes in apoptosis and the PIK3/AKTAKT signal transduction pathway. RESULTS: Enzastaurin showed strong antitumor activity either alone or in combination with radiation both in HNSCC cell lines and in xenograft, with a corresponding reduction in the expression of key radioresponsive proteins. CONCLUSION: Enzastaurin can inhibit tumor growth and improve the efficacy of radiation for HNSCC both in vitro and in vivo. This suggests that enzastaurin may represent a better strategy for the treatment of HNSCC patients, either as a monotherapy or as a radiosensitizer. © 2010 Wiley Periodicals, Inc. Head Neck, 2011. |
| | |
Authors:
|
Xiaoying Yin; D Neil Hayes; Carol G Shores |
Related Documents
:
|
21781227 - Androgen suppresses proliferation of castration-resistant lncap 104-r2 prostate cancer ... 9713687 - The absence of strand-specific repair for the dna polymerase pol gene in deinococcus ra... 10571737 - Evaluation of apoptotic cells induced by ultraviolet light b radiation in epidermal she... 7956617 - Apoptosis occurs in lymphoma cells but not in hepatoma cells following ionizing radiati... 2320127 - Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast. 15465007 - Glutathione precursors replenish decreased glutathione pool in cystinotic cell lines. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-21 |
Journal Detail:
|
Title: Head & neck Volume: 33 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
|
Languages: eng Pagination: 1106-14 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Otolaryngology/Head & Neck Surgery, CB # 7295 LCCC, Chapel Hill, NC 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina. xyyin@med.unc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oncologic and functional results after transhyoid surgical approach for cancer of the base of tongue...
Next Document: Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with...