Document Detail

Antitumor activity of enzastaurin as radiation sensitizer in head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  20967867     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: The antitumor effect of enzastaurin, a specific protein kinase C beta (PKC-β) inhibitor, was tested on head and neck squamous cell carcinoma (HNSCC) cell lines, as well as HNSCC xenograft model.
METHODS: HNSCC cell lines and xenograft were treated with enzastaurin alone or in combination with radiation to evaluate its antitumor effect. Annexin V-FITC staining and Western blot were done to analyze enzastaurin-induced changes in apoptosis and the PIK3/AKTAKT signal transduction pathway.
RESULTS: Enzastaurin showed strong antitumor activity either alone or in combination with radiation both in HNSCC cell lines and in xenograft, with a corresponding reduction in the expression of key radioresponsive proteins.
CONCLUSION: Enzastaurin can inhibit tumor growth and improve the efficacy of radiation for HNSCC both in vitro and in vivo. This suggests that enzastaurin may represent a better strategy for the treatment of HNSCC patients, either as a monotherapy or as a radiosensitizer. © 2010 Wiley Periodicals, Inc. Head Neck, 2011.
Xiaoying Yin; D Neil Hayes; Carol G Shores
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Publication Detail:
Type:  Journal Article     Date:  2010-10-21
Journal Detail:
Title:  Head & neck     Volume:  33     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1106-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Department of Otolaryngology/Head & Neck Surgery, CB # 7295 LCCC, Chapel Hill, NC 27599; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.
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