Document Detail


Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis.
MedLine Citation:
PMID:  19501508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of caspases-3 and -7.
Authors:
Yeonjoong Yong; Soon Young Shin; Young Han Lee; Yoongho Lim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-28
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4367-71     Citation Subset:  IM    
Affiliation:
Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Caspase 3 / metabolism
Caspase 7 / metabolism
Caspases / metabolism*
Cell Cycle
Chemistry, Pharmaceutical / methods
Cyclin A / biosynthesis
Cyclin B1 / biosynthesis
Flow Cytometry
Hela Cells
Humans
Microscopy, Fluorescence / methods
Phytotherapy / methods
Plant Extracts / pharmacology*
Plant Roots / metabolism*
Plants, Medicinal / metabolism*
Podophyllotoxin / analogs & derivatives*,  analysis,  pharmacology
Chemical
Reg. No./Substance:
0/Cyclin A; 0/Cyclin B1; 0/Plant Extracts; 518-28-5/Podophyllotoxin; 69222-20-4/deoxypodophyllotoxin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 7; EC 3.4.22.-/Caspases

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