| Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis. | |
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MedLine Citation:
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PMID: 19501508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of caspases-3 and -7. |
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Authors:
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Yeonjoong Yong; Soon Young Shin; Young Han Lee; Yoongho Lim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-28 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 19 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-14 Completed Date: 2009-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 4367-71 Citation Subset: IM |
Affiliation:
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Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Caspase 3
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metabolism Caspase 7 / metabolism Caspases / metabolism* Cell Cycle Chemistry, Pharmaceutical / methods Cyclin A / biosynthesis Cyclin B1 / biosynthesis Flow Cytometry Hela Cells Humans Microscopy, Fluorescence / methods Phytotherapy / methods Plant Extracts / pharmacology* Plant Roots / metabolism* Plants, Medicinal / metabolism* Podophyllotoxin / analogs & derivatives*, analysis, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cyclin A; 0/Cyclin B1; 0/Plant Extracts; 518-28-5/Podophyllotoxin; 69222-20-4/deoxypodophyllotoxin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 7; EC 3.4.22.-/Caspases |
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