Document Detail

Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis.
MedLine Citation:
PMID:  19501508     Owner:  NLM     Status:  MEDLINE    
An active compound having antitumor activity was isolated from the root of Anthriscus sylvestris. Structural studies revealed that it was deoxypodophyllotoxin (DPPT), and its biological activity was evaluated in HeLa human cervix carcinoma cells. Flow cytometric analysis showed that DPPT arrests the cell cycle in the G2/M phase prior to apoptosis. The mechanisms of action of DPPT involve inhibition of tubulin polymerization, dysregulation of cyclin A and cyclin B1 expression, and activation of caspases-3 and -7.
Yeonjoong Yong; Soon Young Shin; Young Han Lee; Yoongho Lim
Related Documents :
15185338 - Loss of cyclin e requirement in cell growth of an oral squamous cell carcinoma cell lin...
7624138 - Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (cdks)...
16612388 - The reversibility of mitotic exit in vertebrate cells.
15309028 - The fate of pancreatic tumor cell lines following p16 overexpression depends on the mod...
12809598 - Microrna pathways in flies and worms: growth, death, fat, stress, and timing.
18326198 - Characterization of the low-salinity stress in vibrio vulnificus.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-28
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4367-71     Citation Subset:  IM    
Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul 143-701, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Caspase 3 / metabolism
Caspase 7 / metabolism
Caspases / metabolism*
Cell Cycle
Chemistry, Pharmaceutical / methods
Cyclin A / biosynthesis
Cyclin B1 / biosynthesis
Flow Cytometry
Hela Cells
Microscopy, Fluorescence / methods
Phytotherapy / methods
Plant Extracts / pharmacology*
Plant Roots / metabolism*
Plants, Medicinal / metabolism*
Podophyllotoxin / analogs & derivatives*,  analysis,  pharmacology
Reg. No./Substance:
0/Cyclin A; 0/Cyclin B1; 0/Plant Extracts; 518-28-5/Podophyllotoxin; 69222-20-4/deoxypodophyllotoxin; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 7; EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with...
Next Document:  Structure-activity relationship (SAR) of parthenin analogues with pro-apoptotic activity: Developmen...