Document Detail


Antitumor activity of crude polysaccharides isolated from Solanum nigrum Linne on U14 cervical carcinoma bearing mice.
MedLine Citation:
PMID:  17486683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Solanum nigrum Linne (SNL) has been used in traditional Chinese medicine for centuries because of its diuretic and antipyretic effects. The present study examined the effect of the crude polysaccharides isolated from Solanum nigrum Linne (SNL-P) on tumor growth. SNL-P had a significant growth inhibition effect on cervical cancer (U14) of tumor-bearing mice. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly, the expression of Bax increased and the expression of Bcl-2 and mutant p53 decreased dramatically in cervical cancer sections after oral administration of SNL-P for 12 days. Moreover, SNL-P treatment decreased the level of blood serum TNF-alpha. These results indicated that the tumor growth inhibition of SNL-P administration might correlate with the reduction of TNF-alpha level of blood serum, which resulted in a massive necrosis in tumor tissues and the up-regulation of Bax and down-regulation of Bcl-2 and mutant p53 gene expression, which triggered apoptosis in tumor cells. These findings demonstrated that the SNL-P is a potential antitumor agent.
Authors:
Jian Li; Qingwang Li; Tao Feng; Tao Zhang; Kun Li; Rui Zhao; Zengsheng Han; Dawei Gao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  21     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  832-40     Citation Subset:  IM    
Affiliation:
College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, Hebei Province 066004, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antineoplastic Agents, Phytogenic / administration & dosage,  pharmacology*,  therapeutic use
Apoptosis / drug effects
Cell Line, Tumor / drug effects
Female
Kidney / drug effects,  pathology
Liver / drug effects,  pathology
Mice
Mice, Inbred Strains
Phytotherapy*
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Polysaccharides / administration & dosage,  pharmacology,  therapeutic use
Solanum nigrum*
Uterine Cervical Neoplasms / drug therapy,  pathology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts; 0/Polysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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