Document Detail

Antitumor activity of 2-amino-4,4 alpha-dihydro-4 alpha, 7-dimethyl-3H-phenoxazine-3-one, a novel phenoxazine derivative produced by the reaction of 2-amino-5-methylphenol with bovine hemolysate.
MedLine Citation:
PMID:  8862728     Owner:  NLM     Status:  MEDLINE    
2-Amino-4,4 alpha-dihydro-4 alpha,7-dimethyl-3H-phenoxazine-3-one (Phx) was synthesized by the reaction of 2-amino-5-methyl-phenol with bovine hemolysates. Since Phx is a phenoxazine derivative like actinomycin D, which exerts a strong anti-tumor effect by intercalating DNA, we examined the effects of Phx on cell proliferation and cell cycle progression in human epidermoid carcinoma cells (KB cells). Phx inhibited the proliferation of Kb cells in a dose-dependent manner. When KB cells were incubated for 9 h with medium containing 50 microM Phx, a transient accumulation of cells in S and G2/M phase was observed and at 24 h many of cells had lower DNA content. Although Phx had antitumor activity, the drug did not intercalate DNA, showing a different mode of action from actinomycin D.
R Ishida; S Yamanaka; H Kawai; H Ito; M Iwai; M Nishizawa; M Hamatake; A Tomoda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anti-cancer drugs     Volume:  7     ISSN:  0959-4973     ISO Abbreviation:  Anticancer Drugs     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-03-05     Completed Date:  1997-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100823     Medline TA:  Anticancer Drugs     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  591-5     Citation Subset:  IM    
Laboratory of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan.
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MeSH Terms
Cell Cycle / drug effects*
Cell Division / drug effects*
DNA / drug effects
Oxazines / pharmacology*
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one; 0/Oxazines; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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