Document Detail

Antituberculosis cycloartane triterpenoids from Radermachera boniana.
MedLine Citation:
PMID:  21469696     Owner:  NLM     Status:  MEDLINE    
Three new triterpenoids, bonianic acids A (1) and B (2) and 3-O-acetyluncaric acid (3), were isolated from the leaves and twigs of Radermachera boniana, together with six known compounds, ursolic acid (4), oleanolic acid (5), 3-epi-oleanolic acid (6), 3α-O-acetyl-α-boswellic acid (7), ergosterol peroxide (8), and β-sitostenone (9). Ergosterol peroxide (8) and bonianic acids A (1) and B (2) exhibited significant activity against Mycobacterium tuberculosis H37Rv strain.
Ngan B Truong; Cuong V Pham; Huong T M Doan; Hung V Nguyen; Cuong M Nguyen; Hiep T Nguyen; Hong-jie Zhang; Harry H S Fong; Scott G Franzblau; Djaja D Soejarto; Minh V Chau
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-04-06
Journal Detail:
Title:  Journal of natural products     Volume:  74     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-08-17     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1318-22     Citation Subset:  IM    
Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay, Hanoi, Vietnam.
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MeSH Terms
Antitubercular Agents / chemistry,  isolation & purification*,  pharmacology
Bignoniaceae / chemistry*
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Plant Leaves / chemistry
Triterpenes / chemistry,  isolation & purification*,  pharmacology
Grant Support
1-UO1-TW001015-01/TW/FIC NIH HHS; 2-UO1-TW001015-06/TW/FIC NIH HHS; 2U01TW001015-11A1/TW/FIC NIH HHS; 3U01TW001015-10S1/TW/FIC NIH HHS; U01 TW001015/TW/FIC NIH HHS
Reg. No./Substance:
0/3-O-acetyluncaric acid; 0/Antitubercular Agents; 0/Triterpenes; 0/bonianic acid A; 0/bonianic acid B; 511-64-8/cycloartane; P3M2575F3F/ursolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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