Document Detail

Antitubercular natural products: berberine from the roots of commercial Hydrastis canadensis powder. Isolation of inactive 8-oxotetrahydrothalifendine, canadine, beta-hydrastine, and two new quinic acid esters, hycandinic acid esters-1 and -2.
MedLine Citation:
PMID:  9784149     Owner:  NLM     Status:  MEDLINE    
Berberine (4) is responsible for the activity of an extract of a commercial root sample of Hydrastis canadensis against multiply drug resistant Mycobacterium tuberculosis. Two new quinic acid feruloyl esters, compounds 2 and 3, have been isolated from the same source along with canadine (1c), 8-oxotetrahydrothalifendine (1), and beta-hydrastine (5). These were found to be inactive. The structures of the new compounds were elucidated from spectral (1H, 13C, HMQC, HMBC, and H-H COSY) and chemical evidences.
E J Gentry; H B Jampani; A Keshavarz-Shokri; M D Morton; D V Velde; H Telikepalli; L A Mitscher; R Shawar; D Humble; W Baker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  61     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-30     Completed Date:  1998-11-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1187-93     Citation Subset:  IM    
PathoGenesis Corporation, 201 Elliott Avenue West, Suite 150, Seattle, Washington 98119, USA.
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MeSH Terms
Alkaloids / isolation & purification
Antitubercular Agents / chemistry,  pharmacology*
Berberine / analogs & derivatives,  isolation & purification,  pharmacology*
Biological Products / chemistry,  isolation & purification,  pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Quinic Acid / analogs & derivatives,  isolation & purification
Grant Support
Reg. No./Substance:
0/8-oxotetrahydrothalifendine; 0/Alkaloids; 0/Antitubercular Agents; 0/Benzylisoquinolines; 0/Biological Products; 0/hycandinic acid ester-1; 0/hycandinic acid ester-2; 118-08-1/hydrastine; 2086-83-1/Berberine; 522-97-4/canadine; 77-95-2/Quinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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