| Antitrichophyton activity and dermal tissue concentration of pyrrolnitrin. | |
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MedLine Citation:
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PMID: 1003677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Though pyrrolnitrin is surpassed by clotrimazole in in vitro antitrichophyton activity against Trichophyton sp., the therapeutic effect of pyrrolnitrin against experimental trichophytosis in guinea pigs was more potent than that of clotrimazole. The detection of antifungal activity from topically treated guinea pigs suggests that pyrrolnitrin obtains higher concentrations than clotrimazole in dermal tissue. |
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Authors:
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T Kamimura; M Nishida |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Japanese journal of antibiotics Volume: 29 ISSN: 0368-2781 ISO Abbreviation: Jpn J Antibiot Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1977-02-26 Completed Date: 1977-02-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0154402 Medline TA: Jpn J Antibiot Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1003-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antifungal Agents / pharmacology* Clotrimazole / metabolism, pharmacology, therapeutic use Drug Resistance, Microbial Guinea Pigs Male Pyrrolnitrin / metabolism, pharmacology*, therapeutic use Skin / metabolism* Tinea / drug therapy Trichophyton / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 1018-71-9/Pyrrolnitrin; 23593-75-1/Clotrimazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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