Document Detail

Antitrichophyton activity and dermal tissue concentration of pyrrolnitrin.
MedLine Citation:
PMID:  1003677     Owner:  NLM     Status:  MEDLINE    
Though pyrrolnitrin is surpassed by clotrimazole in in vitro antitrichophyton activity against Trichophyton sp., the therapeutic effect of pyrrolnitrin against experimental trichophytosis in guinea pigs was more potent than that of clotrimazole. The detection of antifungal activity from topically treated guinea pigs suggests that pyrrolnitrin obtains higher concentrations than clotrimazole in dermal tissue.
T Kamimura; M Nishida
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Japanese journal of antibiotics     Volume:  29     ISSN:  0368-2781     ISO Abbreviation:  Jpn J Antibiot     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0154402     Medline TA:  Jpn J Antibiot     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1003-6     Citation Subset:  IM    
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MeSH Terms
Antifungal Agents / pharmacology*
Clotrimazole / metabolism,  pharmacology,  therapeutic use
Drug Resistance, Microbial
Guinea Pigs
Pyrrolnitrin / metabolism,  pharmacology*,  therapeutic use
Skin / metabolism*
Tinea / drug therapy
Trichophyton / drug effects*
Reg. No./Substance:
0/Antifungal Agents; 1018-71-9/Pyrrolnitrin; 23593-75-1/Clotrimazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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