Document Detail


Antithyroid drugs inhibit radioiodine-induced increases in thyroid autoantibodies in hyperthyroid Graves' disease.
MedLine Citation:
PMID:  10482369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methimazole (MMI) has been reported to affect prognosis in hyperthyroid Graves' disease patients treated with radioiodine (131I). In the present study, serum concentrations of thyroxine (T4), triiodothyronine (T3), thyroglobulin (Tg), thyrotropin-binding inhibitory immunoglobulin (TBII), thyroglobulin antibody (TgAb), and thyroid-peroxidase antibody (TPOAb) were measured serially for 1 year in patients with Graves' disease after 131I treatment either given alone (group 1, 41 patients) or followed by an antithyroid drug (group 2, 19 patients). The effect of antithyroid drugs on these parameters was analyzed retrospectively. Mean serum concentrations of T4 and T3 both decreased to normal within 3 months after 131I treatment in both groups. Serum Tg concentrations in group 1 showed significant transient increases (about four times the basal value) 1 month after 131I administration. Titers of TBII, TgAb, and TPOAb in group 1 also increased transiently after 131I treatment, with the maximum increase at 3 months. Antithyroid drugs significantly lessened 131I-induced increases in serum concentrations of Tg and all thyroid autoantibodies tested. One year after 131I treatment, 33 of 41 patients (80%) were euthyroid or hypothyroid in group 1; this was true for only 4 of 19 group II patients (22%). The results indicate that administering antithyroid drugs after 131I treatment reduced 131I-induced damage to the thyroid and reduced therapeutic efficacy of 131I in hyperthyroidism. Drug treatment also inhibited release of Tg and blunted 131I-induced increases in titers of thyroid autoantibodies.
Authors:
N Nakazato; K Yoshida; K Mori; Y Kiso; N Sayama; J I Tani; Y Nakagawa; S Ito
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  9     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  775-9     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antithyroid Agents / therapeutic use*
Autoantibodies / analysis*,  biosynthesis
Female
Graves Disease / drug therapy,  immunology*,  radiotherapy
Humans
Immunoglobulins, Thyroid-Stimulating
Iodide Peroxidase / immunology
Iodine Radioisotopes / therapeutic use
Male
Methimazole / therapeutic use*
Middle Aged
Organ Size / drug effects
Receptors, Thyrotropin / analysis,  biosynthesis
Thyroglobulin / analysis,  biosynthesis
Thyroid Gland / immunology*,  pathology
Time Factors
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 0/Autoantibodies; 0/Immunoglobulins, Thyroid-Stimulating; 0/Iodine Radioisotopes; 0/Receptors, Thyrotropin; 0/thyrotropin-binding inhibitory immunoglobulin; 60-56-0/Methimazole; 9010-34-8/Thyroglobulin; EC 1.11.1.8/Iodide Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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