Document Detail

Antithyroid drug therapy for Graves' disease during pregnancy. Optimal regimen for fetal thyroid status.
MedLine Citation:
PMID:  2423874     Owner:  NLM     Status:  MEDLINE    
We compared fetal and maternal serum indexes of thyroid status at delivery in 70 patients with Graves' disease who required therapy with thionamides (such as propylthiouracil) during pregnancy. Forty-three mothers required thionamides until delivery (Group 1), whereas the drugs were discontinued during pregnancy after remission in 27 mothers (Group 2). Maternal free thyroxine levels were closely correlated with cord levels in both groups, being essentially identical in Group 2 but slightly lower in fetuses than in mothers in Group 1. Normal maternal free thyroxine levels did not preclude fetal hypothyroidism. The mothers and fetuses in Group 1 had a significantly higher incidence of antibodies that inhibit thyrotropin binding than did those of Group 2. However, a significant correlation between maternal levels of these antibodies and cord levels of free thyroxine or triiodothyronine was found only in Group 2, in which some maternal and cord thyroxine levels were in the thyrotoxic range at delivery, presumably because therapy was discontinued. These findings indicate that high free thyroxine levels and the presence of antibodies that inhibit binding of thyrotropin are useful indexes of the fetal need for antithyroid treatment, and that the thionamide dosage that maintains maternal free thyroxine levels in a mildly thyrotoxic range seems appropriate for maintaining euthyroid status in the fetus.
N Momotani; J Noh; H Oyanagi; N Ishikawa; K Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  315     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-07-22     Completed Date:  1986-07-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies / analysis
Antithyroid Agents / administration & dosage*
Fetal Blood / analysis
Fetal Diseases / blood,  drug therapy
Fetus / physiology*
Graves Disease / drug therapy*
Infant, Newborn
Pregnancy Complications / drug therapy*
Propylthiouracil / administration & dosage
Thyroid Gland / physiopathology*
Thyrotropin / blood,  immunology
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Antibodies; 0/Antithyroid Agents; 51-52-5/Propylthiouracil; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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