Document Detail


Antithyroid drug-induced fetal goitrous hypothyroidism.
MedLine Citation:
PMID:  21403664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels.
Authors:
Sofie Bliddal; Ase Krogh Rasmussen; Karin Sundberg; Vibeke Brocks; Ulla Feldt-Rasmussen
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-03-15
Journal Detail:
Title:  Nature reviews. Endocrinology     Volume:  7     ISSN:  1759-5037     ISO Abbreviation:  Nat Rev Endocrinol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2012-05-14     Revised Date:  2012-08-06    
Medline Journal Info:
Nlm Unique ID:  101500078     Medline TA:  Nat Rev Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  396-406     Citation Subset:  IM    
Affiliation:
Department of Medical Endocrinology, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antithyroid Agents / adverse effects*
Female
Fetal Diseases / blood,  chemically induced*
Goiter / blood,  chemically induced,  drug therapy
Graves Disease / blood,  chemically induced*
Humans
Hypothyroidism / blood,  chemically induced*,  drug therapy
Pregnancy
Pregnancy Complications / blood,  chemically induced,  drug therapy
Chemical
Reg. No./Substance:
0/Antithyroid Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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