| Antithyroid drug-induced fetal goitrous hypothyroidism. | |
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MedLine Citation:
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PMID: 21403664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal overtreatment with antithyroid drugs can induce fetal goitrous hypothyroidism. This condition can have a critical effect on pregnancy outcome, as well as on fetal growth and neurological development. The purpose of this Review is to clarify if and how fetal goitrous hypothyroidism can be prevented, and how to react when prevention has failed. Understanding the importance of pregnancy-related changes in maternal thyroid status when treating a pregnant woman is crucial to preventing fetal goitrous hypothyroidism. Maternal levels of free T(4) are the most consistent indication of maternal and fetal thyroid status. In patients with fetal goitrous hypothyroidism, intra-amniotic levothyroxine injections improve fetal outcome. The best way to avoid maternal overtreatment with antithyroid drugs is to monitor closely the maternal thyroid status, especially estimates of free T(4) levels. |
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Authors:
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Sofie Bliddal; Ase Krogh Rasmussen; Karin Sundberg; Vibeke Brocks; Ulla Feldt-Rasmussen |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-03-15 |
Journal Detail:
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Title: Nature reviews. Endocrinology Volume: 7 ISSN: 1759-5037 ISO Abbreviation: Nat Rev Endocrinol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-24 Completed Date: 2012-05-14 Revised Date: 2012-08-06 |
Medline Journal Info:
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Nlm Unique ID: 101500078 Medline TA: Nat Rev Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 396-406 Citation Subset: IM |
Affiliation:
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Department of Medical Endocrinology, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antithyroid Agents / adverse effects* Female Fetal Diseases / blood, chemically induced* Goiter / blood, chemically induced, drug therapy Graves Disease / blood, chemically induced* Humans Hypothyroidism / blood, chemically induced*, drug therapy Pregnancy Pregnancy Complications / blood, chemically induced, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antithyroid Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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