Document Detail

Antithymocyte globulin and cyclosporin A are synergistic in an experimental transplantation tolerance model in the rat.
MedLine Citation:
PMID:  10023855     Owner:  NLM     Status:  MEDLINE    
The aim of the present investigation was to study the possible synergistic effect between cyclosporin A (CsA) and antithymocyte globulin (ATG), using the potent immunostimulator, Linomide. DA rats were transplanted with a PVG/c heart to the neck vessels, and the recipients were treated for 10 days with oral CsA (10mg/kg), oral Linomide (160mg/kg) and/or ATG, which was given as a single dose of either 0.02 ml, 0.1 ml or 0.2 ml prior to transplantation. Rats given a combination of ATG and Linomide or CsA and Linomide were used as controls. Synergism between CsA and ATG was tested using the two immunosuppressive drugs given in combination in order to override the challenge of Linomide. CsA or ATG treatment alone resulted in rats with long-term surviving grafts. Addition of Linomide to CsA-treated recipients was followed by early graft rejection. Similarily, Linomide triggered rejection in rats given a low dose of ATG and in recipients given a high dose of ATG if Linomide treatment was prolonged to 21 days. The combination of ATG, CsA and 21 days of Linomide resulted in a significantly prolonged graft survival compared with either ATG + Linomide or CsA + Linomide. These findings demonstrate the synergistic capacity of ATG and CsA in combined immunosuppressive therapy.
M Olausson; D Lukes; J Norrby; Z Qi; H Ekberg; G Gannedahl; G Tufveson; L Mjörnstedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  49     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-25     Completed Date:  1999-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Department of Transplantation and Liver Surgery, Sahlgrenska Universitetssjukhuset, Göteborg, Sweden.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage
Antilymphocyte Serum / administration & dosage,  pharmacology*
Cyclosporine / administration & dosage,  pharmacology*
Dose-Response Relationship, Immunologic
Drug Administration Schedule
Drug Synergism
Drug Therapy, Combination
Graft Survival / drug effects
Heart Transplantation / immunology*
Hydroxyquinolines / administration & dosage
Immune Tolerance* / drug effects
Intubation, Gastrointestinal
Rats, Inbred Strains
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antilymphocyte Serum; 0/Hydroxyquinolines; 59865-13-3/Cyclosporine; 84088-42-6/roquinimex

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