| Antithrombotic treatment for recurrent pregnancy loss? | |
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MedLine Citation:
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PMID: 21781266 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Summary. Background: Recurrent pregnancy loss (RPL) is a major issue for women's health. Acquired and heritable thrombophilias are associated with RPL, this association could reflect a general prothrombotic phenotype rather than a specific thrombophilia. Antithrombotic intervention has therefore been assessed for RPL. Results: Two large randomised trials with untreated control groups showed no benefit from antithrombotic treatment with LMWH and low dose aspirin in women with RPL. These trials had insufficient power to exclude an effect in women with underlying thrombophilia, ≥ 3 losses, or late losses. Conclusions: Antithrombotic intervention should not be recommended for unexplained RPL in general. There may be specific groups such as those with an heritable thrombophilia, or with three or more losses, or second trimester losses that might benefit and where further trials are required. Further there is a need to consider the benefits of LMWH on implantation such as in women undergoing assisted conception therapy. |
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Authors:
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I A Greer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: 9 Suppl 1 ISSN: 1538-7836 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: England |
Other Details:
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Languages: eng Pagination: 302-5 Citation Subset: IM |
Copyright Information:
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© 2011 International Society on Thrombosis and Haemostasis. |
Affiliation:
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Faculty of Health & Life Sciences, University of Liverpool, Liverpool, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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