| Antithrombotic effects of BMY21190, an inhibitor of cAMP phosphodiesterase, in a canine model of coronary artery thrombosis. | |
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MedLine Citation:
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PMID: 8230679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BMY21190, an inhibitor of cyclic AMP phosphodiesterase, has a coronary vasodilating effect. BMY21190 was evaluated for its ability to modify the development of experimental thrombosis resulting from anodal current injury (100 microA for 6 h) of the intimal surface of the left circumflex coronary artery (LCX) in anesthetized dogs. Two groups of dogs were studied. One group received BMY21190 (1 mg/kg) and the other group received an equal volume of vehicle infused into the left jugular vein. After a 30 min administration of BMY21190, heart rate and mean coronary blood flow were increased significantly and mean arterial pressure was decreased. However, the myocardial tension of the left anterior descending coronary artery (LAD) and LCX areas did not increase significantly after BMY21190 infusion. During LCX stimulation, the first LCX occlusion and hyperemic reaction of the control group both occurred significantly earlier than those of the BMY21190 group. BMY21190 treatment reduced the development of the LCX thrombus mass, as compared to that in the controls. In ex vivo studies, platelet aggregation in response to arachidonic acid, ADP or collagen was inhibited by BMY21190. These results suggest that BMY21190 possesses anti-thrombotic and coronary vasodilating effects which may be mediated through the inhibition of cyclic AMP phosphodiesterase. |
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Authors:
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M Minami; E M Driscoll; B R Lucchesi |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 57 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-29 Completed Date: 1993-11-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 979-92 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-AMP Phosphodiesterases
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antagonists & inhibitors* Animals Coronary Circulation / drug effects Coronary Thrombosis / drug therapy* Coronary Vessels / drug effects, physiology Disease Models, Animal Dogs Heart Rate / drug effects Imidazoles / pharmacology, therapeutic use* Male Oxygen / blood Platelet Aggregation / drug effects Platelet Aggregation Inhibitors / pharmacology, therapeutic use Quinolines / pharmacology, therapeutic use* Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Platelet Aggregation Inhibitors; 0/Quinolines; 0/Vasodilator Agents; 154512-24-0/BMY 21190; 7782-44-7/Oxygen; EC 3.1.4.17/3',5'-Cyclic-AMP Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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