Document Detail


Antithrombotic effects of BMY21190, an inhibitor of cAMP phosphodiesterase, in a canine model of coronary artery thrombosis.
MedLine Citation:
PMID:  8230679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BMY21190, an inhibitor of cyclic AMP phosphodiesterase, has a coronary vasodilating effect. BMY21190 was evaluated for its ability to modify the development of experimental thrombosis resulting from anodal current injury (100 microA for 6 h) of the intimal surface of the left circumflex coronary artery (LCX) in anesthetized dogs. Two groups of dogs were studied. One group received BMY21190 (1 mg/kg) and the other group received an equal volume of vehicle infused into the left jugular vein. After a 30 min administration of BMY21190, heart rate and mean coronary blood flow were increased significantly and mean arterial pressure was decreased. However, the myocardial tension of the left anterior descending coronary artery (LAD) and LCX areas did not increase significantly after BMY21190 infusion. During LCX stimulation, the first LCX occlusion and hyperemic reaction of the control group both occurred significantly earlier than those of the BMY21190 group. BMY21190 treatment reduced the development of the LCX thrombus mass, as compared to that in the controls. In ex vivo studies, platelet aggregation in response to arachidonic acid, ADP or collagen was inhibited by BMY21190. These results suggest that BMY21190 possesses anti-thrombotic and coronary vasodilating effects which may be mediated through the inhibition of cyclic AMP phosphodiesterase.
Authors:
M Minami; E M Driscoll; B R Lucchesi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  57     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-29     Completed Date:  1993-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  979-92     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
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MeSH Terms
Descriptor/Qualifier:
3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
Animals
Coronary Circulation / drug effects
Coronary Thrombosis / drug therapy*
Coronary Vessels / drug effects,  physiology
Disease Models, Animal
Dogs
Heart Rate / drug effects
Imidazoles / pharmacology,  therapeutic use*
Male
Oxygen / blood
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / pharmacology,  therapeutic use
Quinolines / pharmacology,  therapeutic use*
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Imidazoles; 0/Platelet Aggregation Inhibitors; 0/Quinolines; 0/Vasodilator Agents; 154512-24-0/BMY 21190; 7782-44-7/Oxygen; EC 3.1.4.17/3',5'-Cyclic-AMP Phosphodiesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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