| Antithrombotic effect of ticlopidine on occlusive thrombi of small coronary arteries in (NZWxBXSB)F1 male mice with myocardial infarction and systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 7723359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the antithrombotic effect of ticlopidine on occlusive thrombi of small coronary arteries in (NZWxBXSB)F1 [(WxB)F1] male mice with myocardial infarction (MI) and systemic lupus erythematosus (SLE). Ticlopidine (3 and 10 mg/kg) was given to the mice as an additive to a standard laboratory diet from the time the mice were aged 16-24 weeks. The higher dose of ticlopidine significantly increased survival rate of the mice. In mice that received 10 mg/kg ticlopidine, the incidence of MI, the percentage of MI area (%MI), and the incidence and number of small coronary arteries with significant stenosis were significantly lower than in controls. The stenosed lesions were divided into occlusive thrombi related to acute MI and intimal thickening related to old MI. No mice had evidence of significant stenosis or thrombosis in the extramyocardial coronary arteries. Glomerulonephritis, blood urea nitrogen (BUN), and circulating immune complexes were not significantly different among the three groups. A high dose of ticlopidine prevented small coronary artery disease and MI and increased the survival of (WxB)F1 male mice, suggesting that this agent has an antithrombotic effect on occlusive thrombi of the small coronary arteries in such mice. |
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Authors:
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H Suzuka; H Fujiwara; M Tanaka; H Yoshifusa; Y Nakamura; Y Shibata |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 25 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-05-22 Completed Date: 1995-05-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 9-13 Citation Subset: IM |
Affiliation:
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Yamashina Laboratories, Nippon Shinyaku Co., Ltd, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Antigen-Antibody Complex / blood Blood Urea Nitrogen Coronary Disease / pathology Coronary Thrombosis / drug therapy, prevention & control* Disease Models, Animal Glomerulonephritis / pathology Lupus Erythematosus, Systemic / drug therapy*, metabolism, mortality Male Mice Myocardial Infarction / drug therapy*, metabolism, mortality Myocardium / cytology, pathology Random Allocation Survival Rate Ticlopidine / administration & dosage, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 55142-85-3/Ticlopidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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