| Antithrombotic therapy in acute coronary syndrome: how far up the coagulation cascade will we go? | |
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MedLine Citation:
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PMID: 20432072 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The contribution of thrombosis to the natural history and clinical expression of advanced atherosclerotic coronary artery disease is well established. Less well understood is the biochemical and pathobiological distinction between normal hemostasis and thrombosis as the proximate cause of acute coronary syndrome. In this article, we summarize an evolving area of interest within the field of antithrombotic therapy--the contact system and the intrinsic pathway of coagulation, focusing our discussion on factors XI, XII, and IX to include their biochemical properties, relationship to arterial thrombosis phenotypes, and rational for future investigation of targeted pharmacotherapy. |
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Authors:
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Becky Woodruff; Bruce Sullenger; Richard C Becker |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current cardiology reports Volume: 12 ISSN: 1534-3170 ISO Abbreviation: Curr Cardiol Rep Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888969 Medline TA: Curr Cardiol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 315-20 Citation Subset: IM |
Affiliation:
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Cardiovascular Thrombosis Research Center, Duke Clinical Research Institute, Duke Translational Research Institute, 2400 Pratt Street, Room 0311 Terrace Level, Durham, NC 27715, USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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