| Antithrombin (human) concentrate infusion in pediatric patients with >50% TBSA burns. | |
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MedLine Citation:
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PMID: 12927992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antithrombin (human) [AT(H)] concentrate infusions have been safely utilized in adult burn patients to counteract subclinical disseminated intravascular coagulopathy and pulmonary complications. OBJECTIVE: AT(H) concentrate was given to two thermally injured pediatric patients to evaluate safety and dosage requirements. DESIGN: The first patient was a 2-year-old with 83% total burn surface area (TBSA) full thickness flame burn and severe inhalation injury. The second patient was a 14-month-old who sustained 56% TBSA deep partial and full thickness scald injury. Each child received 10 infusions of AT(H) concentrate (106 units/kg) in the first 4 days post-injury. RESULT: For these two patients, the plasma AT level (normal range: 100+/-20%) increased, respectively, from 25 and 66% on admission to 224 and 217% on day 1, 114 and 116% on day 2, and 193 and 171% on day 3. Both patients tolerated the infusions well. In one patient, the eschar on all four extremities easily peeled off the subcutaneous tissues along a natural demarcation between viable and non-viable tissue with only a 40cc estimated blood loss (EBL). CONCLUSIONS: AT(H) concentrate is tolerated in the pediatric population in the acute phase of injury. Lack of bleeding during eschar removal may be of benefit to burn excision and grafting. |
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Authors:
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Areta Kowal-Vern; Barbara A Latenser |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 29 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-20 Completed Date: 2003-12-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 615-8 Citation Subset: IM |
Affiliation:
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Department of Trauma, Sumner L. Koch Burn Center, John H. Stroger Jr. Hospital of Cook County, 1901 West Harrison Street, Chicago, IL 60612, USA. avern@rcn.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antithrombins
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administration & dosage*,
adverse effects,
analysis Body Surface Area Burns / blood, drug therapy*, pathology Humans Infant Infusions, Parenteral / methods Male Partial Thromboplastin Time Prothrombin Time |
| Chemical | |
Reg. No./Substance:
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0/Antithrombins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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