Document Detail

Antithrombin (human) concentrate infusion in pediatric patients with >50% TBSA burns.
MedLine Citation:
PMID:  12927992     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Antithrombin (human) [AT(H)] concentrate infusions have been safely utilized in adult burn patients to counteract subclinical disseminated intravascular coagulopathy and pulmonary complications. OBJECTIVE: AT(H) concentrate was given to two thermally injured pediatric patients to evaluate safety and dosage requirements. DESIGN: The first patient was a 2-year-old with 83% total burn surface area (TBSA) full thickness flame burn and severe inhalation injury. The second patient was a 14-month-old who sustained 56% TBSA deep partial and full thickness scald injury. Each child received 10 infusions of AT(H) concentrate (106 units/kg) in the first 4 days post-injury. RESULT: For these two patients, the plasma AT level (normal range: 100+/-20%) increased, respectively, from 25 and 66% on admission to 224 and 217% on day 1, 114 and 116% on day 2, and 193 and 171% on day 3. Both patients tolerated the infusions well. In one patient, the eschar on all four extremities easily peeled off the subcutaneous tissues along a natural demarcation between viable and non-viable tissue with only a 40cc estimated blood loss (EBL). CONCLUSIONS: AT(H) concentrate is tolerated in the pediatric population in the acute phase of injury. Lack of bleeding during eschar removal may be of benefit to burn excision and grafting.
Areta Kowal-Vern; Barbara A Latenser
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  29     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-20     Completed Date:  2003-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  615-8     Citation Subset:  IM    
Department of Trauma, Sumner L. Koch Burn Center, John H. Stroger Jr. Hospital of Cook County, 1901 West Harrison Street, Chicago, IL 60612, USA.
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MeSH Terms
Antithrombins / administration & dosage*,  adverse effects,  analysis
Body Surface Area
Burns / blood,  drug therapy*,  pathology
Infusions, Parenteral / methods
Partial Thromboplastin Time
Prothrombin Time
Reg. No./Substance:

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