Document Detail

Antithrombin III in patients with prosthetic cardiac valves.
MedLine Citation:
PMID:  6665489     Owner:  NLM     Status:  MEDLINE    
When compared to 40 control subjects and to 13 patients with mitral stenosis (8 of them commissurotomized) antithrombin III (AT III) activity, assessed by a clotting technique, was found to be slightly but significantly depressed in the 18 patients with prosthetic valves in mitral position. Decrease of AT III level occurred mainly in patients with metallic Björk-Shiley prostheses in whom mitral valve replacement had been performed more than 12 months before the investigation. Particularly low AT III activities were noted in the three patients who developed thromboembolic complications with lethal evolution. Impaired AT III activity in a patient with prosthetic cardiac valves might be considered as a marker of ongoing in vivo activation of coagulation. Such a finding should be a warning and an indication for intensifying the antithrombotic therapy.
D Bedeleanu; R Vlaicu; S Roman; M Cucuianu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Médecine interne     Volume:  21     ISSN:  0377-1202     ISO Abbreviation:  Med Interne     Publication Date:    1983 Jul-Sep
Date Detail:
Created Date:  1984-02-28     Completed Date:  1984-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506353     Medline TA:  Med Interne     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  169-73     Citation Subset:  IM    
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MeSH Terms
Antithrombin III Deficiency*
Blood Coagulation Tests
Cholinesterases / blood
Fibrinogen / analysis
Heart Valve Prosthesis*
Middle Aged
Mitral Valve Stenosis / surgery*
Postoperative Complications
Thromboembolism / etiology
Reg. No./Substance:
9001-32-5/Fibrinogen; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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