Document Detail

Antithrombin III deficiency in a patient with multifocal osteonecrosis.
MedLine Citation:
PMID:  10987006     Owner:  NLM     Status:  MEDLINE    
The authors examined a 35-year-old man who had multifocal osteonecrosis on the right and left femoral heads, left humeral head, and right scaphoid. The patient previously had a diagnosis of Type I congenital antithrombin III deficiency but had no other risk factors for osteonecrosis. This patient was thought to have systemic thromboembolism because of the increased blood coagulability resulting from antithrombin III deficiency. Thrombophilia (increased likelihood of thrombosis) and hypofibrinolysis (reduced ability to lyse thrombi) have been implicated as causative factors for osteonecrosis. This case shows a possible relationship between thrombophilic antithrombin III deficiency and multifocal osteonecrosis.
T Kubo; H Tsuji; T Yamamoto; H Nakahara; M Nakagawa; Y Hirasawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-28     Completed Date:  2000-09-28     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Antithrombin III Deficiency / complications*,  genetics
Femur Head / pathology,  radiography
Osteonecrosis / diagnosis,  etiology*

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