Document Detail


Antithrombin III and arterial disease.
MedLine Citation:
PMID:  1681216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cross-sectional studies suggest that both low and high antithrombin III levels are associated with the risk of arterial disease, principally ischaemic heart disease (IHD). The prospective relation between antithrombin III and subsequent death from arterial disease has been investigated in 893 men in the Northwick Park Heart Study. Antithrombin III levels were directly correlated with high rather than low levels of factor VII activity and of plasma fibrinogen. There were more deaths from arterial disease in the low and high thirds of the antithrombin III distribution than in the middle third.
Authors:
T W Meade; J Cooper; G J Miller; D J Howarth; Y Stirling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  338     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-10-30     Completed Date:  1991-10-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  850-1     Citation Subset:  AIM; IM    
Affiliation:
MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antithrombin III / metabolism*
Cardiovascular Diseases / blood*,  mortality
Factor VII / metabolism
Fibrinogen / metabolism
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Survival Rate
Chemical
Reg. No./Substance:
9000-94-6/Antithrombin III; 9001-25-6/Factor VII; 9001-32-5/Fibrinogen
Comments/Corrections
Comment In:
Lancet. 1991 Dec 14;338(8781):1525-6   [PMID:  1683944 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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