Document Detail


Antisulfatide antibodies in neuropathy: clinical and electrophysiologic correlates.
MedLine Citation:
PMID:  10751255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the clinical and electrophysiologic characteristics of the neuropathy associated with elevated serum antisulfatide antibodies. METHODS: Clinical, electrophysiologic, morphologic, and laboratory data of 25 patients with significantly elevated (>25,600) antisulfatide antibodies were reviewed. RESULTS: Four groups were distinguished based on clinical and electrophysiologic data: Group 1, eight patients with predominantly small fiber sensory neuropathy (32%); Group 2, five patients with mixed large and small fiber sensory neuropathy (20%); Group 3, seven patients with axonal sensorimotor neuropathy (28%); and Group 4, three patients with demyelinating sensorimotor neuropathy (12%). One additional patient had mononeuritis multiplex and one had ALS. An immunoglobulin M (IgM) monoclonal gammopathy was found in 30% of the patients tested, but not in any of the Group 1 patients with small fiber sensory neuropathy. Serum IgM level was elevated in 12 patients, of whom six had a concomitant monoclonal gammopathy. Morphologic studies in five patients showed predominantly axonal degeneration, with three of the patients also exhibiting additional features of demyelination. CONCLUSIONS: Antisulfatide antibodies are associated with several subtypes of peripheral neuropathy. Predominantly sensory or sensorimotor axonal neuropathies are most common in this series, with the sensory component either small fiber or mixed fiber type. A smaller demyelinating group indistinguishable from patients with chronic inflammatory demyelinating polyradiculopathy was also seen. One third of patients had a concomitant IgM monoclonal gammopathy, and approximately one half had elevated serum IgM.
Authors:
R Dabby; L H Weimer; A P Hays; M Olarte; N Latov
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  54     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1448-52     Citation Subset:  AIM; IM    
Affiliation:
College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Autoantibodies / blood*
Axons / pathology,  ultrastructure
Electromyography
Female
Humans
Male
Middle Aged
Neural Conduction
Pain / etiology
Peripheral Nervous System Diseases / diagnosis*,  immunology*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis,  immunology
Psychomotor Performance
Sulfoglycosphingolipids / immunology*
Sural Nerve / pathology,  ultrastructure
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Sulfoglycosphingolipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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